| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 32.9 | 5.3 | 24.8 | 23.9 | 41.7 | 17.7 | - | 23.5 | 34.6 | 20.1 | 19.1 | 25.3 | 24.4 | 268.9 | |||||
| 2 | Dalvin Cook | RB | FA | 24 | 25.1 | 20.3 | 13 | 19.8 | 11.4 | 26.9 | 23.1 | 11.6 | 24.3 | 11.7 | - | 19.2 | 211.2 | |||||
| 3 | Derrick Henry | RB | BAL | 27.9 | 15.4 | 10.6 | 10.8 | 13.8 | 3.3 | 16.8 | 6.3 | 21.9 | 31.1 | - | 27.5 | 16.9 | 185.4 | |||||
| 4 | Aaron Jones Sr. | RB | MIN | 3.9 | 21 | 14.3 | 11.8 | 42.2 | 4 | 14.3 | 34.6 | 2.9 | 27.3 | - | 3.8 | 16.4 | 180.1 | |||||
| 5 | Nick Chubb | RB | HOU | 8.5 | 15.8 | 13.1 | 36.3 | 9.9 | 23.9 | - | 9.8 | 9.1 | 12.1 | 9.2 | 22.4 | 15.5 | 170.1 | |||||
| 6 | Mark Ingram II | RB | FA | 22.7 | 7.7 | 31.5 | 7.1 | 10.9 | 13.4 | 5.3 | - | 12.4 | 9.4 | 20.5 | 23.8 | 15 | 164.7 | |||||
| 7 | Ezekiel Elliott | RB | FA | 12.3 | 18 | 13.9 | 10.5 | 15.1 | 21.3 | 20.7 | - | 13.9 | 6.3 | 17.3 | 12.6 | 14.7 | 161.9 | |||||
| 8 | Austin Ekeler | RB | WAS | 33.4 | 17.3 | 8.1 | 24.2 | 7.3 | 2.8 | 18.5 | 8.2 | 9.3 | 10.8 | 13.2 | - | 13.9 | 153.1 |