| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derrick Henry | RB | BAL | 31 | 33.6 | 14.4 | 26.3 | 79 | |||||||||||||||
| 2 | Jonathan Taylor | RB | IND | 28.9 | 27.8 | 15 | 23.9 | 71.7 | |||||||||||||||
| 3 | Leonard Fournette | RB | FA | 17 | 24.7 | 15 | 18.9 | 56.7 | |||||||||||||||
| 4 | Damien Harris | RB | FA | 9.8 | 16.8 | 23.3 | 16.6 | 49.9 | |||||||||||||||
| 5 | D'Andre Swift | RB | CHI | 16.4 | 12.7 | 20.4 | 16.5 | 49.5 | |||||||||||||||
| 6 | Alvin Kamara | RB | NO | 24.2 | BYE | 23.9 | 24.1 | 48.1 | |||||||||||||||
| 7 | Darrell Henderson Jr. | RB | FA | 15.9 | 22.7 | 6.4 | 15 | 45 | |||||||||||||||
| 8 | Joe Mixon | RB | HOU | 9.5 | 21.3 | 11.9 | 14.2 | 42.7 |