| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Dalvin Cook | RB | FA | 20.8 | 15.1 | 23.9 | 26.6 | 14.9 | - | - | 46.6 | 24.7 | 147.9 | |||||||||
| 2 | Alvin Kamara | RB | NO | 18.7 | 29.4 | 31.7 | 17.9 | 11.9 | BYE | 14.8 | 16.3 | 20.1 | 140.7 | |||||||||
| 3 | Derrick Henry | RB | BAL | 13.1 | 8.4 | 25 | - | 18.3 | 38.4 | 13.2 | 17.2 | 19.1 | 133.6 | |||||||||
| 4 | Todd Gurley II | RB | FA | 11.7 | 6.1 | 14.2 | 18.3 | 21 | 6.7 | 20.2 | 10.6 | 13.6 | 108.8 | |||||||||
| 5 | James Robinson | RB | FA | 9 | 18 | 24.9 | 10.7 | 5 | 11.3 | 27.7 | - | 15.2 | 106.6 | |||||||||
| 6 | Kareem Hunt | RB | KC | 8.1 | 22.1 | 12.4 | 19.1 | 15.3 | 5.7 | 16.2 | 7.3 | 13.3 | 106.2 | |||||||||
| 7 | Ezekiel Elliott | RB | FA | 24.7 | 16.2 | 11.8 | 12.5 | 22.5 | 4 | 5.1 | 7.3 | 13 | 104.1 | |||||||||
| 8 | Aaron Jones Sr. | RB | MIN | 13.6 | 41.6 | 14.6 | 17.1 | - | 10.1 | BYE | - | 19.4 | 97 |