| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 17.9 | 41.7 | 11.8 | 11.2 | 19.6 | 23.8 | 21 | 126 | ||||||||||||
| 2 | Travis Etienne Jr. | RB | JAC | 13.8 | 7.2 | 32.4 | 20.3 | 19.7 | 22.9 | 19.4 | 116.3 | ||||||||||||
| 3 | Raheem Mostert | RB | LV | 38.2 | 2.5 | 13.8 | 31.2 | 5.1 | 10.6 | 16.9 | 101.4 | ||||||||||||
| 4 | Zack Moss | RB | FA | 20.5 | 9 | 31.5 | 11.9 | 6.2 | 13.4 | 15.4 | 92.5 | ||||||||||||
| 5 | De'Von Achane | RB | MIA | 47.3 | 24 | 20.5 | - | - | - | 30.6 | 91.8 | ||||||||||||
| 6 | Alvin Kamara | RB | NO | - | 8.4 | 15.7 | 10.4 | 17.3 | 23 | 15 | 74.8 | ||||||||||||
| 7 | Kenneth Walker III | RB | SEA | 27.6 | 13.9 | BYE | 14.9 | 11.1 | 7 | 14.9 | 74.5 | ||||||||||||
| 8 | Isiah Pacheco | RB | KC | 13.8 | 21.8 | 12.4 | 9.8 | 12 | 3.7 | 12.3 | 73.5 |