| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jonathan Taylor | RB | IND | 28.9 | 27.8 | 15 | 18.2 | 22.5 | 89.9 | ||||||||||||||
| 2 | Derrick Henry | RB | BAL | 31 | 33.6 | 14.4 | 6.8 | 21.5 | 85.8 | ||||||||||||||
| 3 | Darrell Henderson Jr. | RB | FA | 15.9 | 22.7 | 6.4 | 21.3 | 16.6 | 66.3 | ||||||||||||||
| 4 | Damien Harris | RB | FA | 9.8 | 16.8 | 23.3 | 14 | 16 | 63.9 | ||||||||||||||
| 5 | Joe Mixon | RB | HOU | 9.5 | 21.3 | 11.9 | 21.1 | 16 | 63.8 | ||||||||||||||
| 6 | Alvin Kamara | RB | NO | 24.2 | BYE | 23.9 | 13.6 | 20.6 | 61.7 | ||||||||||||||
| 7 | Leonard Fournette | RB | FA | 17 | 24.7 | 15 | 4.3 | 15.3 | 61 | ||||||||||||||
| 8 | Najee Harris | RB | LAC | 20.2 | 18.7 | BYE | 18 | 19 | 56.9 |