| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derrick Henry | RB | BAL | 7.7 | 41.7 | 16.4 | 23.7 | 31 | 33.6 | 14.4 | 6.8 | - | 21.9 | 175.3 | |||||||||
| 2 | Jonathan Taylor | RB | IND | 11.6 | 5.3 | 7.2 | 17.4 | 28.9 | 27.8 | 15 | 18.2 | 32 | 18.2 | 163.4 | |||||||||
| 3 | Joe Mixon | RB | HOU | 21 | 7.1 | 9.4 | 12.7 | 9.5 | 21.3 | 11.9 | 21.1 | 23 | 15.2 | 137 | |||||||||
| 4 | Austin Ekeler | RB | WAS | 11.7 | 13.5 | 16.7 | 26.5 | 27.9 | 5.5 | - | 18.4 | 8.2 | 16.1 | 128.4 | |||||||||
| 5 | Alvin Kamara | RB | NO | 15.1 | 3 | 17.8 | 12 | 24.2 | BYE | 23.9 | 13.6 | 16.4 | 15.8 | 126 | |||||||||
| 6 | James Conner | RB | ARI | 5.3 | 2.6 | 17.3 | 18.6 | 9.7 | 7.1 | 12.4 | 14.2 | 35.3 | 13.6 | 122.5 | |||||||||
| 7 | Najee Harris | RB | LAC | 4.9 | 14.1 | 14.2 | 15.1 | 20.2 | 18.7 | BYE | 18 | 13.8 | 14.9 | 119 | |||||||||
| 8 | Cordarrelle Patterson | RB | FA | 6.7 | 18.9 | 10.2 | 29.6 | 11.4 | - | 12.1 | 13.2 | 13.6 | 14.5 | 115.7 |