It’s Week 6, and fantasy football lineups are starting to look like Frankenstein’s monster — part brilliance, part horror, and a whole lot of questionable decision-making. The bye weeks are here, injuries are piling up, and that “sure thing” Flex from Week 2 now looks like a pumpkin left out since Labor Day. Luckily, our Featured Pros have you covered with their latest round of Start and Sit recommendations, highlighting this week’s must-starts and must-bench duds. Let’s dive in before another “game-time decision” ruins your Sunday.
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Fantasy Football Week 6 Start/Sit Advice
Sleepers
Which player outside of the top 100 in the FantasyPros Flex rankings is a good sleeper start, and why do you think he has upside this week?
Tyquan Thornton (WR – KC)
“Tyquan Thornton continues to shine despite only a 45% snap share. Monday night marked the third time this season that he finished in the top 30 of fantasy wide receivers. The Lions are going to be playing without two of their top corners for the foreseeable future. Thornton currently leads the league in average depth of target (aDOT) and makes a good start in deeper leagues.”
– Terrell Furman Jr. (FantasyPros)
“Tyquan Thornton has quietly been the best pass-catcher on the Kansas City Chiefs this season. He is the team’s highest-scoring fantasy wide receiver, ranking as the WR26 for the year, averaging 11.6 PPR fantasy points per game. While the veteran has had five or fewer targets in all but one game, Thornton doesn’t need significant touches to make an impact because of his big-play abilities. He has scored 12+ fantasy points in three of the past four weeks, including in Week 5, thanks to a 34-yard reception. While his fantasy value will take a hit when Rashee Rice returns from his suspension, Thornton is a solid Flex option against the Detroit Lions this week. They have surrendered 35.6 fantasy points per game to wide receivers, the seventh-most in the NFL. Furthermore, the Lions will be without multiple starters in the secondary because of injury.”
– Mike Fanelli (FantasyPros)
“Put some respect on Tyquan Thornton‘s name. He is currently WR20 on the season and is averaging over 20 yards per reception, which means you are getting two points per catch. He has three touchdowns on the year and continues to see targets. This should be a shootout with Detroit, and I want pieces of that offense this week. Bonus deep sleeper: Ryan Flournoy.”
– David Heilman (Sports Gambling Podcast Network)
“I’m digging through the crates a bit, but Tyquan Thornton looks like a diamond in the rough heading into Week 6 against the Lions. Detroit uses man coverage on dropbacks at the fifth-highest rate in the league. Thornton leads all Chiefs pass-catchers in win rate against man coverage (22.9%) and ranks second in yards per route run (2.33). If Patrick Mahomes has the time in the pocket, he should be able to connect on deep shots down the field to Thornton. He’s worth a look in deeper leagues and is a great DFS play as well.”
– Kyle Zeigler (Fantasy In Frames)
Isaiah Bond (WR – CLE)
“Isaiah Bond. Kimani Vidal is probably a popular pick, so I’ll pivot to Bond. Pittsburgh ranks in the bottom 10 against fantasy receivers in 2025, and the game script is likely pointing to Cleveland throwing as they play from behind. Bond is an explosive receiver with a growing role (55%+ of the snaps in three straight games), and Cedric Tillman is on IR.”
– Kevin Roberts (The DFS Build)
Duds
Which player inside the top 40 in the FantasyPros Flex rankings is likely to disappoint fantasy managers this week?
Derrick Henry (RB – BAL)
“Derrick Henry. Is anyone still trusting him? Godspeed if so, as Henry has failed to top (gulp) even 11 fantasy points in any of his last four games. Volume and falling into the end zone could always save him, but the Ravens are more predictable sans Lamar Jackson, and the Rams (third against fantasy backs) are a nightmare spot.”
– Kevin Roberts (The DFS Build)
“Baltimore Ravens running back Derrick Henry is poised to disappoint fantasy managers this week due to mounting challenges for the Ravens’ offense. The possibility of another missed game for quarterback Lamar Jackson, who has an “outside shot” at playing through his hamstring injury, would force backup Cooper Rush into a less dynamic role, limiting Henry’s receiving opportunities and overall volume. With the Ravens already at a dismal 1-4 record and facing a tough Los Angeles Rams defense, Baltimore could easily fall into a negative game script, forcing them to abandon the run early. Their injury woes compound the issue, as key defenders like safety Kyle Hamilton (shoulder), linebacker Roquan Smith (ankle), cornerback Marlon Humphrey (knee) and defensive tackle Nnamdi Madubuike (neck) are all sidelined, potentially allowing the Rams to build a lead and cap Henry’s touches. Even against a middling Rams run defense, Henry’s recent inefficiency (averaging just 3.5 yards per carry without Jackson) signals low-upside production in this spot.”
– Aaron St Denis (Fantasy Sports Advice Network)
“Unfortunately, it has to be Derrick Henry, who’s likely to disappoint. With Lamar Jackson expected to miss the game with a hamstring injury and the Ravens on a Week 7 bye, it makes sense to sit him. Baltimore could get blown out at home again, this time by Matthew Stafford and the Rams. Henry salvaged his fantasy day last week against Houston with a touchdown, but averaged just 2.2 yards per carry. He also had only eight carries for 42 yards against the Chiefs in a game where Baltimore was trailing. King Henry can hit the bench with all the other peasants.”
– Kyle Zeigler (Fantasy In Frames)
“Sadly, it is Derrick Henry. If Lamar Jackson plays this week, it may be a different story; however, the Ravens with Cooper Rush at quarterback versus the Rams just screams no go. Teams can stack the box against Baltimore to focus solely on Henry without Jackson in the lineup, daring Rush to beat them over the top. As shown last week, it did not work out all that well. If Baltimore goes down, they will have to start throwing the ball, leaving Henry on the outside looking in, especially on passing downs. While Henry is a great buy right now with the team’s bye next week giving Baltimore a chance to get healthy, this isn’t the week we see The King go off.”
– Ed Birdsall (Talking Points Sports)
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