| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jonathan Taylor | RB | IND | 34 | 24.6 | 53.4 | 37.3 | 112 | |||||||||||||||
| 2 | James Conner | RB | ARI | 40.3 | 15.4 | 20.9 | 25.5 | 76.6 | |||||||||||||||
| 3 | Austin Ekeler | RB | WAS | 11.2 | 14.9 | 41.5 | 22.5 | 67.6 | |||||||||||||||
| 4 | Christian McCaffrey | RB | SF | 14.6 | 26.1 | 24.9 | 21.9 | 65.6 | |||||||||||||||
| 5 | Dalvin Cook | RB | FA | 15.2 | 20.8 | 22.5 | 19.5 | 58.5 | |||||||||||||||
| 6 | A.J. Dillon | RB | PHI | 13 | 26.8 | 15.7 | 18.5 | 55.5 | |||||||||||||||
| 7 | Nick Chubb | RB | HOU | 30.3 | BYE | 22.4 | 26.4 | 52.7 | |||||||||||||||
| 8 | Joe Mixon | RB | HOU | 28 | BYE | 24.3 | 26.2 | 52.3 |