| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derrick Henry | RB | BAL | 25.7 | 31 | 35.6 | 16.4 | 27.2 | 108.7 | ||||||||||||||
| 2 | Jonathan Taylor | RB | IND | 20.4 | 31.9 | 28.8 | 18 | 24.8 | 99.1 | ||||||||||||||
| 3 | Leonard Fournette | RB | FA | 16.9 | 21 | 30.7 | 17 | 21.4 | 85.6 | ||||||||||||||
| 4 | D'Andre Swift | RB | CHI | 8.9 | 22.4 | 17.7 | 28.4 | 19.4 | 77.4 | ||||||||||||||
| 5 | Alvin Kamara | RB | NO | 12 | 29.2 | BYE | 33.9 | 25 | 75.1 | ||||||||||||||
| 6 | Austin Ekeler | RB | WAS | 29.5 | 32.9 | 9.5 | - | 24 | 71.9 | ||||||||||||||
| 7 | Najee Harris | RB | LAC | 21.1 | 22.2 | 24.7 | BYE | 22.7 | 68 | ||||||||||||||
| 8 | Darrell Henderson Jr. | RB | FA | 16.6 | 16.9 | 24.7 | 9.4 | 16.9 | 67.6 |