| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Todd Gurley II | RB | FA | 29.3 | 34.5 | 26.6 | 27.5 | 13.9 | 22 | 25.6 | 153.8 | |||||||||||
| 2 | Kareem Hunt | RB | KC | 15.4 | 24.5 | 32.1 | 14.6 | 32.1 | 9.6 | 21.4 | 128.3 | |||||||||||
| 3 | James Conner | RB | ARI | 30.5 | 24.9 | - | 33.2 | 22.3 | 13.3 | 24.8 | 124.2 | |||||||||||
| 4 | Christian McCaffrey | RB | SF | 15.3 | 6.6 | 8 | 17.6 | 27.7 | 31.8 | 17.8 | 107 | |||||||||||
| 5 | Saquon Barkley | RB | PHI | 24.9 | 28.9 | 17.4 | 11.1 | BYE | 10 | 18.5 | 92.3 | |||||||||||
| 6 | Melvin Gordon III | RB | FA | 18 | 33 | - | - | 18.3 | 22.5 | 23 | 91.8 | |||||||||||
| 7 | Alvin Kamara | RB | NO | 3.9 | BYE | 13.5 | 19.6 | 29.6 | 22.2 | 17.8 | 88.8 | |||||||||||
| 8 | James White | RB | FA | 13.7 | 9.2 | 21.7 | 15.4 | 22.3 | 2.6 | 14.2 | 84.9 |