| Player | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | TTL | AVG |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Anthony Sherman | KC | 11 | 7 | 10 | 0 | 2 | 0 | 0 | 0 | 0 | bye | 2 | 3 | 2 | 5 | 10 | 4 | 4 | 60 | 5.0 |
| Clyde Edwards-Helaire | KC | 46 | 48 | 52 | 0 | 43 | 49 | 27 | 33 | 25 | bye | 40 | 47 | 0 | 46 | 45 | 0 | 0 | 501 | 41.8 |
| Darrel Williams | KC | 23 | 10 | 16 | 0 | 29 | 23 | 1 | 8 | 18 | bye | 20 | 8 | 31 | 5 | 22 | 47 | 4 | 265 | 17.7 |
| David Johnson | HOU | 48 | 56 | 45 | 36 | 45 | 55 | 54 | bye | 7 | 0 | 0 | 0 | 37 | 0 | 55 | 50 | 62 | 550 | 45.8 |
| Duke Johnson Jr. | HOU | 14 | 0 | 0 | 25 | 17 | 19 | 20 | bye | 53 | 54 | 47 | 42 | 34 | 30 | 0 | 0 | 0 | 355 | 32.3 |
| James Robinson | JAC | 35 | 38 | 30 | 52 | 43 | 19 | 57 | bye | 50 | 53 | 41 | 63 | 60 | 40 | 36 | 0 | 0 | 617 | 44.1 |
| Chris Thompson | JAC | 13 | 31 | 30 | 16 | 30 | 15 | 0 | bye | 19 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 155 | 19.4 |
| Marlon Mack | IND | 11 | 0 | 0 | 0 | 0 | 0 | bye | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 11 | 11.0 |
| Jonathan Taylor | IND | 27 | 49 | 24 | 33 | 31 | 37 | bye | 26 | 21 | 17 | 46 | 0 | 33 | 34 | 38 | 40 | 55 | 511 | 34.1 |
| Nyheim Hines | IND | 42 | 9 | 20 | 25 | 21 | 21 | bye | 16 | 23 | 39 | 29 | 48 | 23 | 22 | 16 | 29 | 12 | 395 | 24.7 |