| Player | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | TTL | AVG |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ronald Jones II | TB | 6 | 26 | 12 | 13 | 10 | 14 | 14 | 9 | bye | 0 | 15 | 12 | 2 | 8 | 22 | 35 | 20 | 0 | 218 | 14.5 |
| Leonard Fournette | TB | 42 | 31 | 26 | 64 | 46 | 47 | 39 | 37 | bye | 31 | 46 | 54 | 61 | 66 | 33 | 0 | 0 | 0 | 623 | 44.5 |
| Giovani Bernard | TB | 17 | 6 | 33 | 0 | 17 | 12 | 11 | 13 | bye | 14 | 8 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 138 | 13.8 |
| Tony Pollard | DAL | 20 | 21 | 29 | 18 | 31 | 26 | bye | 19 | 24 | 32 | 22 | 31 | 28 | 0 | 29 | 25 | 19 | 0 | 374 | 24.9 |
| Ezekiel Elliott | DAL | 70 | 44 | 53 | 46 | 47 | 63 | bye | 55 | 33 | 38 | 46 | 47 | 45 | 54 | 44 | 42 | 45 | 37 | 809 | 47.6 |
| Corey Clement | DAL | 1 | 0 | 3 | 0 | 0 | 0 | bye | 0 | 5 | 13 | 0 | 0 | 0 | 31 | 0 | 7 | 0 | 17 | 77 | 7.0 |
| Mekhi Sargent | Multi | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 6 | 1.5 |
| Derrick Henry | TEN | 40 | 67 | 49 | 59 | 49 | 43 | 50 | 54 | 0 | 0 | 0 | 0 | bye | 0 | 0 | 0 | 0 | 0 | 411 | 51.4 |
| Jeremy McNichols | TEN | 23 | 21 | 18 | 40 | 15 | 0 | 10 | 17 | 26 | 16 | 0 | 0 | bye | 27 | 23 | 26 | 6 | 0 | 268 | 20.6 |
| Khari Blasingame | TEN | 9 | 0 | 0 | 0 | 0 | 9 | 0 | 0 | 0 | 0 | 0 | 5 | bye | 0 | 0 | 9 | 0 | 14 | 46 | 9.2 |