NFL DFS Lineup Advice: Best Stacks (Week 4)

We’re gearing up for another jam-packed NFL Week 4 slate, featuring several big-time matchups to target in DFS. Games we’ll be looking at with great stacking opportunities include the Washington Commanders vs. Atlanta Falcons, Indianapolis Colts vs. Los Angeles Rams, and Chicago Bears vs. Las Vegas Raiders.

There were several stacks we highlighted in NFL DFS Lineup Advice: Best Stacks (Week 3) edition that yielded significant production. Follow me on X at Matt_MacKay_ for more NFL DFS analysis and free picks during each week of the 2025 NFL season.

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NFL DFS Week 4: Best DFS Stacks

DraftKings Salary: $50,000 | FanDuel Salary: $60,000

Washington Commanders vs. Atlanta Falcons

This matchup between the Commanders and Falcons has a ton of potential for fantasy points from both offenses. Atlanta was shockingly shut out on the road against Carolina last week, while Washington beat Las Vegas 41-24 in a high-scoring outing.

It’s the second consecutive week Marcus Mariota gets the nod under center for the Commanders. He’s facing his former team, creating a revenge game angle, plus, Mariota wound up with 21.3 fantasy points during his 2025 debut against the Raiders.

Mariota remains a cheap quarterback to feature in a stack. His dual threat ability makes him a viable option, going 6-40-1 as a ball carrier last week. Atlanta’s defense is stout up front but they were unable to stop the Panthers’ ground game in Week 3.

Pair two of Washington’s top skilled players, Deebo Samuel and Zach Ertz, with Mariota. Ertz is cheap, between $4.1K and $5K, while finishing with at least three receptions and 26 yards in all three games played. Last week was the first time he failed to find the end zone.

Samuel was more of a ball carrier than a wideout with Mariota. However, he recorded a season-high three carries and will not be competing for targets against Terry McLaurin, who has been ruled out against the Falcons.

I’ll continue rolling out the Michael Penix and Drake London stack. It’s cheaper than it’s been due to the Falcons’ woeful performance last week, yet London still finished with five receptions for 55 yards on eight targets.

Washington couldn’t stop Las Vegas’ passing attack. Penix should bounce back at home and be at his best playing inside of a dome. London has red zone targets but hasn’t been able to convert any into touchdowns yet, which should change against the Commanders in Week 4.

Indianapolis Colts vs. Los Angeles Rams

One of the most highly-anticipated games in Week 4 features the Los Angeles Rams hosting the Indianapolis Colts. These teams have a combined 5-1 record, with Daniel Jones leading the Colts to a surprising 3-0 start.

The Colts’ defense is a favorable matchup for Los Angeles. Indianapolis has surrendered five passing touchdowns and 4.8 YPC, so we’re going to start by inserting Matthew Stafford and Davante Adams.

This tandem has a strong rapport in their first season together, with Adams logging eight targets in every game. As a result, he’s scored 14.6 and 25.6 fantasy points in each of the last two weeks against the Titans and Eagles.

Blake Corum is more of a cheap longshot who could boost lineups if he winds up with red zone touches. The Colts’ run defense is vulnerable and he logged a season-high eight carries for 53 yards against Philadelphia last week.

Jones is an expensive prospect but he’s worth stacking with rookie tight end Tyler Warren. Warren had his lowest fantasy output in Week 3, finishing with 6.8 fantasy points, yet he’s logged five targets or more in every game this season.

Expect Warren to be more of a focal point against a Rams defense that is stingy in its secondary and against the run. This will force Jones to heavily target his security blanket in the middle of the field.

Jones holds standalone value due to his usage as a ball carrier at the goal line. He’s finished with 26 rushing yards twice and scored three rushing touchdowns in the first two weeks. Also has thrown for at least one touchdown and 228 yards, without an interception.

Chicago Bears vs. Las Vegas Raiders

Oddsmakers have this matchup between the Bears and Raiders set to 47.5 points, indicating a high-scoring shootout in the Desert on Sunday. Rome Odunze and Caleb Williams have been a big-time moneymaker for us this season.

The Bears’ WR1 is now the most expensive he’s been in 2025, however, it’s still worth the price of admission, especially when paired with Williams. Chicago’s signal-caller is coming off of a dominant four touchdown performance against the Cowboys and draws another soft matchup against the Raiders’ pass defense in Week 4.

D’Andre Swift is a versatile running back for Chicago. He has between 3-5 targets in all three games, while logging between 12-17 carries. Note he’s currently questionable, but if he’s cleared to play, Swift should finish with 15-20 touches to log at least 10 fantasy points at a decent salary.

Geno Smith connected with WR Tre Tucker eight times on nine targets in Week 3. This yielded an insane 8-145-3 stat line for his wideout, which I don’t expect to happen again in Week 4.

I’ll back Smith in a stack, returning home against a Bears defense ranked 29th in net yards gained per pass attempt. Instead of Tucker, let’s stack Smith with Jakobi Meyers.

Meyers has at least 63 receiving yards and three receptions in every game this season. He had 22 targets in the first two weeks, before his target share dipped in Week 3, finishing with 9.3 fantasy points despite only getting four targets.

Averaging 76 yards per game and 13.3 fantasy points per game, without a touchdown, is impressive. I think Meyers finds the end zone against Chicago and returns to a bigger target share, meaning he’s a priority add in a Raiders stack with Smith.

Matthew MacKay is a featured writer for BettingPros and FantasyPros. For more from Matthew, check out his archive and follow him @Matt_MacKay_.