NFL DFS Lineup Advice: Best Stacks (Week 13)

The NFL Week 13 slate saw all four underdogs win outright on Thanksgiving and Black Friday. We may be in store for more upsets during Sunday’s slate, which means there’s big value in targeting select stacks in NFL DFS contests this weekend.

Notable matchups with high point totals include the Arizona Cardinals vs. Tampa Bay Buccaneers, Houston Texans vs. Indianapolis Colts, and Buffalo Bills vs. Pittsburgh Steelers. Games played in tough elements include the San Francisco 49ers vs. Cleveland Browns, Atlanta Falcons vs. New York Jets, and Minnesota Vikings vs. Seattle Seahawks.

I’m back with my favorite NFL DFS stacks to construct ahead of Sunday’s matchups. Follow me on X at Matt_MacKay_ for more NFL analysis and free picks.

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NFL DFS Week 13: Best DFS Stacks

DraftKings Salary: $50,000 | FanDuel Salary: $60,000

Arizona Cardinals vs. Tampa Bay Buccaneers

Jacoby Brissett continues to be a DFS goldmine. The Cardinals’ QB1 has recorded at least 19.4 fantasy points per game in all six starts this season due to his high passing volume.

We’ll stack Brissett with Michael Wilson and Greg Dortch. Yes, Marvin Harrison‘s back on the field against Tampa Bay this week but Brissett has built a strong rapport with Arizona’s other two wideouts, particularly Wilson.

The third-year wideout has recorded 36.5 and 24.8 fantasy points in back-to-back games against the 49ers and Jaguars. Dortch has also logged between 16.8 and 18.6 fantasy points during this stretch. Tampa Bay’s pass defense is increasingly porous, setting up a great matchup for a Brissett-Wilson-Dortch triple stack.

We’re going to pay up to grab Baker Mayfield and Emeka Egbuka as the top Buccaneers stack to insert into lineups. Mayfield is dealing with an AC joint injury he suffered against the Los Angeles Rams but he’s gritty and can likely play through it.

Egbuka has been quiet lately but he finds himself in a favorable matchup against the Cardinals, who are allowing 6.2 net yards gained per pass attempt, ranked 15th-highest in the league. Tampa Bay may be chasing points at home against Brissett and the Arizona passing attack, justifying the elevated salaries of a Mayfield-Egbuka stack.

Houston Texans vs. Indianapolis Colts

A big-time AFC South tilt sends the Houston Texans on the road to face the Indianapolis Colts. Daniel Jones is dealing with a lower body injury that may keep him a bit less effective as a ball carrier, so we’ll be stacking multiple skilled position players on the Colts instead.

We’re going to pay up to acquire Jonathan Taylor into lineups. Houston’s defense is among the best in the NFL but they do tend to give up explosives to opposing running backs. Taylor is having an MVP-caliber season, so with Jones’ mobility limited, expect a heavy dosage of Taylor leading to massive production.

Tyler Warren, Indianapolis’ first-round tight end, has been extremely reliable during his rookie campaign. Warren has gone under 10 fantasy points against the Steelers, Titans, and Chiefs during his last four starts, so we’re getting a good discount on his latest salary. Any double-digit outing is a strong return on investment at this price.

C.J. Stroud is back from an extensive stay in the concussion protocol. The Texans won all three games without Stroud as a starter, so he’ll look to ease his way back into the lineup with targets to wideouts like Christian Kirk and Jayden Higgins.

Higgins is a rookie but he’s developing fast, scoring three touchdowns across his past five games played. Kirk is a veteran and just returned to the lineup when Stroud went out, so there’s a lot of opportunity for the slot wideout to return value, especially coming off a 5-54-1 state line on six targets with backup QB Davis Mills.

Finally, Woody Marks, Houston’s fourth round rookie running back, is worth the elevated salary. Marks has overtaken Nick Chubb as the Texans’ RB1, handling between 10-18 carries, along with three to five targets in five starts. It’s led to Marks scoring double-digit fantasy points in four of 11 games played this season.

Buffalo Bills vs. Pittsburgh Steelers

Buffalo is coming off its Week 12 loss to the Houston Texans. The Bills have not looked consistent all season long, especially when opposing defenses can shut down their rushing attack.

Pittsburgh’s defense is tailored to stop the run. This means we’re likely going to see big passing numbers from reigning NFL MVP, Josh Allen, and his favorite target, WR Khalil Shakir.

Shakir has logged two 20-point fantasy performances in 2025. This includes last week against Houston’s stout secondary. Shakir has only been held under 11.3 fantasy points once in his last five starts. The Steelers have been gashed by the pass all season, ranked 12th in most touchdowns allowed (19), so a stack of Allen-Shakir could return big value in DFS lineups on the road in Pittsburgh.

On the other sideline, we’re going to roll out a cheaper three-man stack including DK Metcalf-Jaylen Warren-Kenneth Gainwell. Aaron Rodgers is back from injury but in this run-centric Arthur Smith offense, I like how both Steelers running backs stack up against Buffalo’s porous run defense.

The Bills are among the worst run defenses in the league right now. Warren and Gainwell have both handled double-digit touches, especially Gainwell as a receiver out of the backfield.

Warren guarantees you a floor of 10 fantasy points, averaging 12.2 on FanDuel and 13.4 on DraftKings in 10 games played. Gainwell has been explosive, racking up five total touchdowns. He’s also recorded 30-plus receiving yards in four starts.

DK Metcalf was used as a ball carrier to find the end zone against Chicago last week. Now that Rodgers is back under center, expect Metcalf to get some more quality targets in the passing game.

He’s been held under 10 fantasy points in four of his past six games played. Yet Metcalf’s size advantage in the red zone makes him a scoring threat that warrants consideration in DFS lineups.

Matthew MacKay is a featured writer for BettingPros and FantasyPros. For more from Matthew, check out his archive and follow him @Matt_MacKay_.