Fantasy Football Player Notes

Brandon Aiyuk made significant contributions with 50 receiving yards, including a 28-yard touchdown (4 targets). Aiyuk's uber efficiency allows him to be a fantasy star even when the volume is coming his way. Behind CMC, he's by far the best fantasy asset on the 49ers. And the schedule is juicy for him to have some epic spike weeks down the stretch. You better take his receiving yards over.

Deebo Samuel was Brock Purdy's top target, catching 7 passes for 79 yards (2 red-zone targets). His target share was 29.0% (9 targets). Samuel also found the end zone rushing, contributing 15 yards on 4 carries. When everybody is healthy, Samuel is the most likely odd man out in the offense. That wasn't the case in this matchup versus Seattle, but that won't be the case every week.