| Player | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | TTL | AVG |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patrick Mahomes II | KC | 65 | 67 | 56 | 70 | 66 | 71 | 68 | 61 | 60 | bye | 79 | 60 | 67 | 66 | 65 | 76 | 54 | 0 | 1051 | 65.7 |
| Jared Goff | DET | 70 | 66 | 70 | 75 | 57 | 70 | 75 | 86 | bye | 66 | 62 | 84 | 58 | 65 | 66 | 79 | 69 | 57 | 1175 | 69.1 |
| Lamar Jackson | BAL | 64 | 75 | 72 | 55 | 70 | 71 | 57 | 65 | 57 | 54 | 66 | 71 | bye | 72 | 70 | 68 | 53 | 0 | 1040 | 65.0 |
| C.J. Stroud | HOU | 77 | 84 | 56 | 71 | 58 | 63 | bye | 58 | 72 | 75 | 66 | 60 | 66 | 48 | 0 | 0 | 58 | 56 | 968 | 64.5 |
| Desmond Ridder | ATL | 52 | 82 | 67 | 58 | 77 | 83 | 65 | 31 | 0 | 22 | bye | 62 | 68 | 72 | 52 | 0 | 8 | 51 | 850 | 56.7 |
| Bryce Young | CAR | 77 | 59 | 0 | 72 | 70 | 69 | bye | 67 | 71 | 60 | 59 | 74 | 72 | 80 | 66 | 66 | 54 | 52 | 1068 | 66.8 |
| Deshaun Watson | CLE | 74 | 87 | 66 | 0 | bye | 0 | 12 | 0 | 67 | 77 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 383 | 63.8 |
| Jake Browning | CIN | 4 | 0 | 0 | 0 | 0 | 0 | bye | 0 | 0 | 0 | 34 | 43 | 73 | 55 | 70 | 64 | 74 | 52 | 469 | 52.1 |
| Joe Burrow | CIN | 52 | 60 | 77 | 53 | 82 | 54 | bye | 63 | 70 | 64 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 602 | 60.2 |
| Kenny Pickett | PIT | 63 | 54 | 62 | 49 | 66 | bye | 59 | 28 | 65 | 65 | 58 | 71 | 30 | 0 | 0 | 0 | 0 | 0 | 670 | 55.8 |