My two favorite games to stack have modest spreads and totals of 49.5 points and 47.5, respectively. The core studs and values/punts feature both running backs from one of the highlighted game stacks. However, there’s also a quarterback-wideout stack in those sections, and two players projected to lead their positions in scoring will be featured below. Let’s dive into our NFL DFS lineup advice, picks and predictions for Week 6.
NFL DFS Picks & Predictions: Week 6
Suggested Game Stacks
Game: Panthers vs. Cowboys
Spread/Total: DAL -3.0/49.5 Points
Tetairoa McMillan has been targeted at least eight times in all five games of his rookie season, cleared 60 receiving yards three times and secured at least five receptions three times. T-Mac’s underlying data is impressive. According to the data suite at Fantasy Points, among 70 wide receivers with at least 100 routes this year, McMillan is seventh in air yards share (41.8%), 17th in target share (22.8%), tied for 18th in targets per route run (0.24), 14th in first-read rate (28.4%) and 13th in expected fantasy points per game.
The big-bodied rookie wide receiver has a Charmin-soft matchup. According to Pro Football Reference, the Cowboys have coughed up the most DraftKings points per game (47.1) and the most FanDuel points per game (38.6) to wide receivers this season. Thus, the lineup optimizer projects McMillan as the WR8 at both DFS outlets, with the WR6 value score (the measure of points per $1,000 of salary) at DraftKings and the WR4 value score at FanDuel.
Jalen Coker is an intriguing punt in GPPs. The Panthers opened his 21-day practice window, and he fully participated in practice on Wednesday. Presumably, they’ll activate Coker this week for the most fantasy-friendly matchup for wide receivers. From Week 5 through the end of Coker’s rookie season in 2024, he had the following stats.
- 74.7% route participation
- 11.1-yard average depth of target (aDOT)
- 21.9% air yards share
- 14.8% target share
- 0.17 targets per route run
- 19.2% first-read rate
- 32 receptions (3.2 per game)
- 478 receiving yards (47.8 per game)
- 1.86 yards per route run (Y/RR)
- Two receiving touchdowns
- Four end-zone targets
Coker exceeded all expectations as an undrafted free agent. He has big-play potential and an ideal matchup, making him worth a dice roll in GPPs.
Bryce Young hasn’t built on his encouraging finish to last year. Nevertheless, according to StatHead, he’s scored at least 14.0 DraftKings points and at least 13.0 FanDuel points in five of nine starts at home since Dave Canales was hired as Carolina’s head coach last season. Young has the optimal matchup, with the Cowboys permitting the most DraftKings points per game (28.7) and the most FanDuel points per game (27.3) to quarterbacks this season. Therefore, Young has the QB1 value score at DraftKings and the QB5 value score at FanDuel.
I’ll hold off on discussing either of the running backs in this contest since they’re featured below. Instead, let’s look at the Cowboys’ signal-caller and their pass-catching weapons. According to RotoViz’s pace app, the Cowboys are tied for the sixth-highest situation-neutral pass rate (60%) this season. Dak Prescott has rewarded Brian Schottenheimer for the pass-heavy play-calling tendencies. According to Pro Football Reference, Prescott is first in pass attempts (195), third in passing yards per game (271.2) and tied for third in passing touchdowns (10) this season. He’s not much of a running threat, but Prescott has averaged 10.0 rushing yards per game and scored one rushing touchdown in 2025. We project Prescott to tie for the QB2 in fantasy points at both DFS outlets this week.
CeeDee Lamb played only seven offensive snaps in Week 3 before exiting the contest with an ankle injury. He’ll likely miss another week, and Lamb’s absence has narrowed the target distribution primarily around George Pickens and Jake Ferguson. Pickens’ and Ferguson’s receiving numbers since Week 3 are in the following table.
Pickens is projected as the WR5 at DraftKings and the WR6 at FanDuel this week. Meanwhile, Ferguson is projected as the TE2 at both DFS sites, and I’ll be overweight to the field on Ferguson in Week 6.
Game: Jaguars vs. Seahawks
Spread/Total: JAC -1.0/47.5 Points
Brian Thomas has fallen way short of expectations in his sophomore season. Regardless, he has stellar underlying data and had a season-high 80 receiving yards against the Chiefs on Monday Night Football in Week 5. Among 70 wide receivers with at least 100 routes this year, BTJ is 15th in air yards share (37.3%), 23rd in target share (21.9%), tied for 21st in targets per route run (0.23) and 20th in expected fantasy points per game. The second-year pro’s season-best showing last week could be the catalyst for better days ahead.
Travis Etienne has taken a stranglehold on Jacksonville’s lead running back duties. He’s handled 77 of the backfield’s 105 rush attempts (73.3%) among the remaining backs after they traded Tank Bigsby following Week 1. Etienne has parlayed his hefty workload on the ground into 88.6 rushing yards per game, 5.75 yards per carry, 3.16 yards before contact per attempt, 2.60 yards after contact per attempt, a 6.5% explosive run rate, 0.14 missed tackles forced per attempt and two rushing touchdowns.
Etienne’s 36.0% route participation rate also bests LeQuint Allen‘s 24.2% route participation rate and Bhayshul Tuten‘s 11.3% route participation rate. Etienne has an 8.3% target share, 0.21 targets per route run, a 1.7-yard aDOT, nine receptions (1.8 per game), 41 receiving yards (8.2 per game) and one receiving touchdown this season. The speedy running back is game-script proof and has a high ceiling.
Sam Darnold is slinging it. Among 34 quarterbacks with at least 75 dropbacks this year, Darnold has Pro Football Focus’ (PFF’s) second-highest passing grade, is tied for the seventh-highest big-time throw rate (5.6 BTT%) and has the lowest turnover-worthy play rate (1.3 TWP%). Among qualified quarterbacks, Darnold is first in adjusted net yards per pass attempt (8.98). However, Darnold is 10th in passing yards per game (249.2) because he’s only 21st in pass attempts (134).
Darnold will likely be cut loose this week. The Jaguars have faced the second-highest situation-neutral pass rate (66%) this year, making them a pass-funnel defense. We project Darnold to be the QB8 at both DFS providers, with the QB3 value score at DraftKings.
Jaxon Smith-Njigba has been on the same page as Darnold, and he’s having an exceptional season. Among wide receivers with at least 100 routes this year, JSN is second in air yards share (47.1%), second in target share (31.4%), second in targets per route run (0.35), third in first-read rate (42.1%), third in receptions (34 at 6.8 per game), second in receiving yards per game (106.8), first in yards per route run (4.34 Y/RR) and tied for 19th in touchdown receptions (two). We project JSN to be the WR2 at both DFS outlets this week, with the WR5 value score at DraftKings.
Tory Horton is an intriguing contrarian game-stacking option from this contest. The rookie wideout’s 13.9-yard aDOT is a stylistic fit for this matchup. According to the data suite at Fantasy Points, the Jaguars have faced the seventh-deepest aDOT (8.3), tied for facing the eighth-highest deep-throw rate (12.2%) and tied for the third-most deep throws against (24).
AJ Barner is a viable punt at tight end this week. He’s third on the Seahawks in route participation rate (60.7%), third in target share (10.9%), third in receptions (14 at 2.8 per game), third in receiving yards (134 at 26.8 per game) and first in touchdown receptions (four). Barner isn’t a world-beating athlete. Still, as his forthcoming relative athletic score (RAS) will illustrate, he’s not some unathletic plodder, either.
Barner is cheap exposure to this game stack or a useful punt in a possible shootout.
Core Studs
- Puka Nacua is projected as the WR1 at both DFS outlets, with the WR3 value score at DraftKings and the WR2 value score at FanDuel. He’s been borderline unstoppable. Among wideouts with at least 100 routes this season, Nacua is tied for 20th in air yards share (35.0%), first in target share (33.7%), first in targets per route run (0.39), second in first-read rate (42.6%), first in receptions (52 at 10.4 per game), first in receiving yards per game (117.6), second in yards per route run (3.72) and first in expected fantasy points per game.
- Javonte Williams is projected as the RB5 at DraftKings and FanDuel, with the RB1 value score at the former and tied for the RB4 value score at the latter. Among 47 running backs with at least 25 rush attempts this year, Williams is ninth in rush attempts (79), third in rushing yards per game (89.4), fourth in yards per carry (5.66), second in yards after contact per attempt (3.68), 19th in explosive run rate (5.1%) and tied for second in rushing touchdowns (five). Williams has also added 3.4 receptions per game, 15.6 receiving yards per game and one receiving touchdown. Carolina has yielded a whopping 4.8 yards per carry to running backs this year, and Williams should have plenty of opportunities to gash them for the favored Cowboys.
- Drake Maye is projected as the QB1 at both sites, with the QB2 value score at DraftKings and the QB1 value score at FanDuel. Among quarterbacks with at least 75 dropbacks, Maye is PFF’s ninth-ranked passer, and he’s settled into a groove in Josh McDaniels’ offense. The second-year pro has cleared 265 passing yards three times, thrown multiple touchdowns three times, bested 10 rushing yards five times and rushed for a score twice. He can score points through the air and on the ground, and he could get an increase in plays this week because the Saints play at a breakneck pace.
Value Plays/Punts
- Rico Dowdle is projected as the RB8 at both DFS sites, with the RB4 value score at DraftKings and the RB1 value score at FanDuel. Chuba Hubbard is dealing with a calf injury, and Dowdle should provide the Panthers with motivation to rest Hubbard again this week after rushing for 206 yards and one touchdown last week. Dowdle also secured three of his four targets for 28 yards.
- The Dolphins needed others to step up in the passing attack after losing Tyreek Hill for the season to a knee injury in Week 4, and Darren Waller did his part. After running 10 routes, earning four targets and securing three receptions for 27 yards and two touchdowns in his season debut in Week 4, Waller jumped to 26 routes, five targets, five receptions, 78 receiving yards and a touchdown in Week 5.
- Stefon Diggs is projected as the WR10 this week, with the WR1 value score at FanDuel. He had extra motivation in Week 5 against the Bills. Yet, Diggs has eye-catching numbers this year. Among wide receivers with at least 100 routes this season, Diggs is 32nd in air yards share (29.1%), tied for third in targets per route run (0.30), 10th in receptions (29), 13th in receiving yards per game (71.8) and third in yards per route run (3.21).
Week 6 Top 3 Underdog Player Props
Javonte Williams: 66.5 Rushing Yards – Higher
Williams is averaging 89.4 rushing yards per game, with a median of 76 this year. He had 97 and 135 rushing yards in Dallas’s two wins and 85 in their tie. Williams has exceeded 75 rushing yards in four straight games, notably higher than his line of 66.5 rushing yards. We project him to rush for 78.6 yards against the Panthers this week.
Tetairoa McMillan: 64.5 Receiving Yards – Higher
T-Mac has averaged 70.2 receiving yards per game, with a median of 68. The rookie wideout eclipsed 64.5 receiving yards in two of three losses. Finally, the Cowboys have allowed an NFL-high 188.8 receiving yards per game to wideouts.
Jonathan Taylor: 89.5 Rushing Yards – Higher
Jonathan Taylor leads the NFL in rushing yards per game this season, with 96.0. Additionally, according to StatHead, Taylor has surpassed 89.5 rushing yards in six of 10 victories since last year, averaging 115 per game in those contests. We project Taylor to rumble for 95.8 yards against the Cardinals.
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Josh Shepardson is a featured writer at FantasyPros. For more from Josh, check out his archive and follow him @BChad50.
