NFL DFS Lineup Advice: Best Stacks (Week 11)

NFL Week 11 has a ton of divisional matchups as we march through the second half of the season. Only two teams are on bye, the Colts and Saints, so there is ample opportunity to construct DFS lineups with a lot of high-value stacks.

Key matchups we’re targeting on this Week 11 slate include the Panthers vs. Falcons, Bengals vs. Steelers, and 49ers vs. Cardinals. Other notable games during the afternoon windows include an NFC West showdown between the Rams and Seahawks, Chiefs vs. Broncos, Buccaneers vs. Bills, and Chargers vs. Jaguars.

Below are my favorite NFL Week 11 DFS stacks to prioritize in contests. Follow me on X at Matt_MacKay_ for more NFL analysis and free picks.

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NFL DFS Week 11: Best DFS Stacks

DraftKings Salary: $50,000 | FanDuel Salary: $60,000

Carolina Panthers vs. Atlanta Falcons

Atlanta will look to avenge its 30-0 shutout loss on the road to Carolina earlier this season when they host the Panthers in Week 11. The Falcons have lost four straight games, while Carolina is 4-2 in its previous six games played.

Rico Dowdle is a must-start in DFS this week. Dowdle has been Carolina’s primary offense and Atlanta is a bottom-tier run defense, allowing 4.9 YPC in 2025. Instead of a Bryce Young stack, we’ll pair the Panthers’ RB1 with WR1 Tetairoa McMillan.

McMillan, a top-ten draft pick in the 2025 class, has been busy with targets. He’s logged eight or more targets in two of the Panthers’ previous three games. McMillan has only found the end zone in one game, but he’s still managed to record six other double-digit outings. Expect McMillan to lead the Panthers downfield, while Dowdle finishes possessions in the end zone.

On the Falcons’ sideline, we’re going to run a triple-stack of Michael Penix Jr., Tyler Allgeier, and Drake London. London has a whopping 33 percent target share in Atlanta’s offense, scoring 24-plus fantasy points in four of his previous five games.

Carolina’s defensive strength is its pass defense. Despite their talent, London’s poised to continue his heater in a must-win game for the Falcons. This means Penix Jr. is an automatic stack candidate with his favorite target.

Instead of Bijan Robinson, who is the most expensive player in this matchup, we’re going to roll with Tyler Allgeier as the cheaper option. Allgeier has been staying busy, scoring three rushing touchdowns in Atlanta’s previous three games.

While he’s not involved in the Falcons’ passing attack, Allgeier draws a top-tier matchup against a porous Carolina run defense. Penix-London-Allgeier is the best high-value stack to construct in this NFC South tilt at Mercedes-Benz Stadium.

Cincinnati Bengals vs. Pittsburgh Steelers

The first matchup between the Bengals and Steelers was electrifying. Joe Flacco and Aaron Rodgers aired it out in prime-time, with Cincinnati pulling off the upset at home. Now, it’s Pittsburgh’s turn to host in this AFC North rivalry.

Let’s stack Rodgers, who is averaging 15.9 fantasy points per game, with RB1 Jaylen Warren. Warren is in a great matchup against the Bengals’ struggling defense, where he’ll rack up chunk yards in the ground and passing attack. Rodgers is coming off his worst performance of the season against the Chargers, so expect a much improved version against a bottom of the barrel defense.

Pat Freiermuth is an explosive playmaker who Rodgers likes to target downfield and in the red zone. He’s only logging three to four targets lately, however, the tight end has turned these into a pair of double-digit outings, including his season-best 28.6 fantasy points against the Bengals in Week 7.

Ja’Marr Chase remains too highly priced. Let’s opt for Tee Higgins, who is over $2,000 cheaper, and stack him with Flacco. The Bengals’ veteran signal-caller likes to air it out and he may only have a couple of games left before Joe Burrow returns from injury.

Higgins just logged a season-high 36.1 fantasy points during Cincinnati’s loss to the Bears in Week 9. He caught seven of nine targets for 121 yards and two touchdowns. Pittsburgh’s secondary is pedestrian, allowing 15 touchdowns and 6.2 net yards per pass attempt, so Flacco-Higgins is a high-value stack to deploy in contests this week.

San Francisco 49ers vs. Arizona Cardinals

The 49ers and Cardinals will meet for the second time in 2025 following San Francisco’s 16-15 win in Week 3. Brock Purdy is back to full health following a multi-week absence due to injury.

While it’s not an easy matchup on paper, with Arizona’s pass defense playing well against most teams, Purdy should be hyper-targeting star tight end George Kittle. Purdy and Kittle have great rapport and their combined salary isn’t too steep for a 49ers’ stack.

Arizona is where we’re going to roll out the triple-stack. Moving off Kyler Murray in favor of Jacoby Brissett means the passing attack has become more consistent and threatening. This should continue against a banged-up San Francisco defense that is ranked bottom-10 in passing touchdowns and net yards per pass attempt allowed.

Trey McBride is worth the price of admission. The Cardinals’ TE1 has thrived with Brissett, logging between nine and 13 targets during all four of Brissett’s starts. This has turned into 14 to 26.2 fantasy points per game. Expect it to continue against the 49ers’ porous defense in Week 11.

Finally, we’ll roll out Arizona’s RB1, Emari Demercado. He’s become the Cardinals’ de facto RB1, totaling 64 rushing yards or more in three of his last four starts. He also logged four targets against Seattle in Week 10, finishing with 3-40 as a receiver.

Matthew MacKay is a featured writer for BettingPros and FantasyPros. For more from Matthew, check out his archive and follow him @Matt_MacKay_.