It’s Week 6, and fantasy football lineups are starting to look like Frankenstein’s monster — part brilliance, part horror, and a whole lot of questionable decision-making. The bye weeks are here, injuries are piling up, and that “sure thing” flex from Week 2 now looks like a pumpkin left out since Labor Day. Luckily, our Featured Pros have you covered with their latest round of Start and Sit recommendations, highlighting this week’s must-starts and must-bench duds. Let’s dive in before another “game-time decision” ruins your Sunday.
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Fantasy Football Week 6 Start/Sit Advice
Duds
Which player inside the top 40 in the FantasyPros flex rankings is likely to disappoint fantasy managers this week?
Derrick Henry (RB – BAL)
“Derrick Henry. Is anyone still trusting him? Godspeed if so, as Henry has failed to top (gulp) even 11 fantasy points in any of his last four games. Volume and falling into the endzone could always save him, but the Ravens are more predictable sans Lamar, and the Rams (3rd against fantasy RBs) are a nightmare spot.”- Kevin Roberts (The DFS Build)
“Baltimore Ravens running back Derrick Henry is poised to disappoint fantasy managers this week due to mounting challenges for the Ravens’ offense. The possibility of another missed game for quarterback Lamar Jackson, who has an “outside shot” at playing through his hamstring injury, would force backup Cooper Rush into a less dynamic role, limiting Henry’s receiving opportunities and overall volume. With the Ravens already at a dismal 1-4 record and facing a tough Los Angeles Rams defense, Baltimore could easily fall into a negative game script, forcing them to abandon the run early. Their injury woes compound the issue, as key defenders like safety Kyle Hamilton (shoulder), linebacker Roquan Smith (ankle), cornerback Marlon Humphrey (knee), and defensive tackle Nnamdi Madubuike (neck) are all sidelined, potentially allowing the Rams to build a lead and cap Henry’s touches at under 15 carries. Even against a middling Rams run defense, Henry’s recent inefficiency (averaging just 3.5 yards per carry without Jackson) signals low-upside production in this spot.”
– Aaron St Denis (Fantasy Sports Advice Network)
“Unfortunately, it has to be Derrick Henry, who’s likely to disappoint. With Lamar Jackson expected to miss the game with a hamstring injury and the Ravens on a Week 7 bye, it makes sense to sit him. Baltimore could get blown out at home again, this time by Stafford and the Rams. Henry salvaged his fantasy day last week against Houston with a touchdown, but averaged just 2.2 yards per carry. He also had only eight carries for 42 yards against the Chiefs in a game where Baltimore was trailing. King Henry can hit the bench with all the other peasants.”
– Kyle Zeigler (Fantasy In Frames)
“Sadly, it is Derrick Henry. If Lamar Jackson plays this week, it may be a different story; however, the Ravens with Cooper Rush at QB versus the Rams just screams no go. Teams can stack the box against Baltimore to focus solely on Henry without Jackson in the lineup, daring Cooper Rush to beat them over the top. As shown last week, it did not work out all that well. If Baltimore goes down, they will have to start throwing the ball, leaving Henry on the outside looking in, especially on passing downs. While Henry is a great buy right now with the team’s bye next week giving Baltimore a chance to get healthy, this isn’t the week we see The King go off.”
– Ed Birdsall (Talking Points Sports)
Garrett Wilson (WR – NYJ)
“Unfortunately, Garrett Wilson gets the Denver Broncos’ stingy defense this week. He should see a lot of Patrick Surtain, who last year matched up with Wilson for 25 routes (2 rec, 22 yards). Despite the production this season, this is a good enough reason to downgrade him this week.”
– Terrell Furman Jr. (FantasyPros)
“Garrett Wilson is the WR5 for the year, averaging 19 PPR fantasy points per game. However, most of his fantasy production comes in the fourth quarter when the New York Jets are chasing points in garbage time. The former Ohio State star has averaged 10.5 fantasy points per game over the first three quarters compared to 8.1 in the fourth. More importantly, Wilson faces an elite Denver Broncos defense early Sunday morning in London. They have held wide receivers to 27.7 fantasy points per game, the fifth-fewest in the NFL. Furthermore, the Broncos have surrendered only 4.8 receptions on 7.8 targets for 44.4 receiving yards and 9.2 fantasy points per game to opposing No. 1 wide receivers, allowing 9.3 or fewer in all but one contest despite facing A.J. Brown and Ja’Marr Chase the past two weeks. Unfortunately, Wilson will likely finish Week 6 outside the top 24 wide receivers.”
– Mike Fanelli (FantasyPros)
“I think that Garrett Wilson will disappoint fantasy managers in Week 6 due to a combination of matchup difficulty and offensive issues. The Jets face the Denver Broncos this week, an elite pass defense that is likely to deploy a premier shadow corner against him, drastically lowering his ceiling. Furthermore, the Jets’ offense is projected to have one of the lowest team totals of the week, with Justin Fields‘ play style limiting passing volume. These factors will result in a frustrating week for his owners.”
– Luke Renton (The Franchise Tag UK)
Cam Skattebo (RB – NYG)
“I know he’s a fun player, but Cam Skattebo is going to disappoint again. He struggled against the New Orleans Saints this past week and will face an even tougher defense in the Philadelphia Eagles this week. He’s always been touchdown dependent, but he’s going to be even more so this week as he’ll likely have trouble getting even 50 rushing yards this week.”
– Trevor Land (FlurrySports)
A.J. Brown (WR – PHI)
“A.J. Brown continues to get ranked on name recognition and upside. He is a boom-bust play that, unfortunately, has been a boom in only 20% of games this year. His good games are great, finishing WR3. His bad games could lose you the week, scoring less than 1 point in two games and a combined 8.5 points in his four bad games. He is 40th in the flex rankings as we speak, he won’t be inside my top-40.”
– David Heilman (Sports Gambling Podcast Network)
“A.J. Brown feels like a rinse and repeat answer here, just like I’ve been saying since the pre-season. Tre Tucker scored 3.5 PPR points less in Week 3 alone than Brown has all season. Outside of the Rams game, when the Eagles were trailing by three scores and had to throw non-stop, Brown is averaging three catches for 21 yards in the four other games. The Eagles were leading the majority of the time in all four of those games. What do you think will happen on a short week against the lowly Giants?”
– Michael Tomlin (Fantasy Six Pack)
Xavier Worthy (WR – KC)
“The player inside the top 40 in the FantasyPros flex rankings that is likely to disappoint fantasy managers this week is Xavier Worthy (WR-KC). His fantasy value is heavily tied to big plays, and he’s facing a defense built to eliminate those explosive passes. Opposing secondaries have been shading coverage his way since his breakout game, and his target share has dipped below 15% in two straight weeks. With Rashee Rice and Travis Kelce commanding the high-percentage routes and Patrick Mahomes spreading the ball around more, Worthy’s production becomes boom-or-bust—and this matchup profiles as a “bust” week. Expect limited volume, a low floor, and touchdown dependency against a defense that hasn’t allowed a 40+ yard reception all season.”
– Jeff Boggis (Fantasy Football Empire)
Drake London (WR – ATL)
“Drake London finally had a breakout in week 4 with 8/110/1 against the Commanders. That has moved him all the way up to WR4in half-PPR rankings. Drake London is a top-tier wide receiver, but that ranking could lead to disappointment for fantasy managers due to Michael Penix‘s inconsistency, and he is facing a Buffalo defense that is only allowing 154 yards/game. He should maintain a high target share; however, owners should lower expectations for London Week 6, but get excited for some upcoming weeks against weaker defenses.”
– Adam Dove (The Fantasy Couriers)
Ja’Marr Chase (WR – CIN)
“If you wanted to get out of the Ja’Marr Chase business, Week 5’s splash game gives you a chance. No mat£ter who takes the QB snaps this week, Cincinnati is likely to get thumped by a rested Green Bay team and defense.”
– Scott Pianowski (Yahoo! Sports)
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