The Chargers placed DB Derwin James Jr. on injured reserve. (Source: Chargers.com)
Fantasy Impact: James suffered a setback in his recovery. He will miss at least the next four games.
Tre' Harris is good to go for Sunday's game against the Rams.
Fantasy Impact: Harris is good to go after the bye week. He remains off the fantasy radar.
Ladd McConkey is off the injury report for Sunday's game against the Rams.
Fantasy Impact: McConkey has been able to clear the concussion protocol. It has been a rough season injury wise for him. He remains a WR2 when he is healthy.
Marquez Valdes-Scantling (rib) is set to play in Sunday's game against the Kansas City Chiefs. (Source: Los Angeles Chargers on Twitter)
Fantasy Impact: Valdes-Scantling is now off of the injury report after being limited at practice earlier in the week with a rib issue. He will play in Week 6 but doesn't project to make a big impact for the Chargers for the foreseeable future.
KeAndre Lambert-Smith (hamstring) is questionable for Sunday's game against the Kansas City Chiefs. (Source: Los Angeles Chargers on Twitter)
Fantasy Impact: The Chargers are undecided on whether or not to activate Lambert-Smith for Week 6, so he carries a questionable tag heading into the weekend. He won't be very involved even if fully cleared to play against the Chiefs on Sunday, however.
Quentin Johnston (chest) is off of the injury report for Sunday's game against the Kansas City Chiefs. (Source: Los Angeles Chargers on Twitter)
Fantasy Impact: Johnston was dealing with a chest injury at practice throughout the week, but it seems to be nothing more than a minor issue, as he is off of the team's injury report heading into the weekend. He will play on Sunday and should see more work than usual with Tre' Harris (hamstring) set to be sidelined for the Chargers.
Brenen Thompson (quad) is questionable for Week 6's matchup against the Kansas City Chiefs. (Source: Los Angeles Chargers on Twitter)
Fantasy Impact: Thompson is uncertain to play in Week 6 and is officially questionable with a quad issue. If he's cleared to play, he may see more work than usual with Tre' Harris (hamstring) set to be sidelined for the Chargers.
Kayode Awosika (leg) is unavailable for Sunday's game against the Kansas City Chiefs. (Source: Los Angeles Chargers on Twitter)
Fantasy Impact: The Chargers will be without Awosika on Sunday due to the lingering leg issue that he's dealing with. Joe Alt (neck) has also been ruled out, which means that their offensive front will be much weaker than usual in a matchup against the Chiefs.
Joe Alt (neck) has been ruled out for Sunday's game against the Kansas City Chiefs. (Source: Los Angeles Chargers on Twitter)
Fantasy Impact: Alt has already been ruled out for Sunday's game, which has been the expectation since early in the week. His next chance to play will come in Week 7, but it's very possible that he will miss more time beyond this game, which is bad news for Los Angeles' entire offense.
Charlie Kolar (arm) practiced in a full capacity on Thursday. (Source: Los Angeles Chargers on Twitter)
Fantasy Impact: The veteran tight end practiced in a full capacity for a second-straight day on Thursday, indicating that he's nearly fully healthy at this point. He should play in Week 6 but doesn't project to be fantasy relevant moving forward.
The Chargers placed QB Trey Lance on injured reserve. (Source: Pro Football Talk on Twitter)
Fantasy Impact: Lance will miss at least the next four games.
Trevor Penning has been ruled out for Sunday's game against the Broncos. (Source: Noah Furtado on Twitter)
Fantasy Impact: Penning was unable to clear concussion protocol in time for Sunday.
Donte Jackson has been ruled out for Sunday's game against the Broncos. (Source: Noah Furtado on Twitter)
Fantasy Impact: The Chargers secondary will be without both Jackson and Derwin James Jr.
Rashawn Slater (ankle) missed another practice session on Thursday. (Source: Denver Broncos)
Fantasy Impact: It looks like Slater is going to be sidelined in Week 5 after missing two-straight practices to start the week. Los Angeles is dealing with several other injuries to key starters on their offensive line right now, so they seem to be in a lot of trouble ahead of a tough matchup against the Broncos in Week 5.
Dalvin Tomlinson has been ruled out for Sunday's game against the Seahawks.
Fantasy Impact: Tomlinson will be sidelined with a hamstring injury.
Keaton Mitchell (ankle) is without an injury designation for Sunday's game against the Seattle Seahawks. (Source: Brian Nemhauser on Twitter)
Fantasy Impact: The veteran is going to be good to go on Sunday, despite being listed on the injury report throughout the week due to an ankle issue. He will continue to play second fiddle behind Omarion Hampton on this offense, although his exact snap share remains worth keeping an eye on this week.
Cole Strange (pec) was a limited participant at practice on Wednesday. (Source: Los Angeles Chargers on Twitter)
Fantasy Impact: Los Angeles has multiple starting linemen on their injury report right now, including Strange, who was limited at practice due to a pec injury. He looks likely to play in Week 3, although we won't know for sure until later on in the week.
The Chargers placed TE David Njoku on injured reserve. (Source: Adam Schefter on Twitter)
Fantasy Impact: Njoku was carted off the field in Sunday's game against the Raiders. With Charlie Kolar (forearm) also placed on IR, Oronde Gadsden is the only healthy tight end on the Chargers right now.
The Chargers placed veteran LB Denzel Perryman on injured reserve. (Source: Tom Pelissero on Twitter)
Fantasy Impact: Perryman will miss at least the first four games of the season.
The Chargers placed Scott Matlock on injured reserve.
Fantasy Impact: Matlock will miss at least the first four games of the season.
