It’s Week 6, and fantasy football lineups are starting to look like Frankenstein’s monster — part brilliance, part horror, and a whole lot of questionable decision-making. The bye weeks are here, injuries are piling up, and that “sure thing” Flex from Week 2 now looks like a pumpkin left out since Labor Day. Luckily, our Featured Pros have you covered with their latest round of Start and Sit recommendations, highlighting this week’s must-starts and must-bench duds. Let’s dive in before another “game-time decision” ruins your Sunday.
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Fantasy Football Week 6 Start/Sit Advice
Sleepers
Which player outside of the top 100 in the FantasyPros Flex rankings is a good sleeper start, and why do you think he has upside this week?
Tyquan Thornton (WR – KC)
“Tyquan Thornton continues to shine despite only a 45% snap share. Monday night marks the third time this season that he has finished in the top 30 wide receivers. The Lions are going to be playing without two of their two corners for the foreseeable future. Thornton currently leads the league in aDOT and makes a good start in deeper leagues.”
– Terrell Furman Jr. (FantasyPros)
“Tyquan Thornton has quietly been the best pass catcher on the Kansas City Chiefs this season. He is the team’s highest-scoring fantasy wide receiver, ranking as the WR26 for the year, averaging 11.6 PPR fantasy points per game. While the veteran has had five or fewer targets in all but one game, Thornton doesn’t need significant touches to make an impact because of his big-play abilities. He has scored 12 or more fantasy points in three of the past four weeks, including in Week 5, thanks to a 34-yard reception. While his fantasy value will take a hit when Rashee Rice returns from his suspension, Thornton is a solid flex option against the Detroit Lions this week. They have surrendered 35.6 fantasy points per game to wide receivers, the seventh-most in the NFL. Furthermore, the Lions will be without multiple starters in the secondary because of injury.”
– Mike Fanelli (FantasyPros)
“Put some respect on Tyquan Thornton’s name. He is currently WR20 on the season and is averaging over 20 yards per reception, which means you are getting 2 points per catch. He has three touchdowns on the year and continues to get targets. This should be a shootout with Detroit, and I want pieces of that offense this week. Bonus: Deep sleeper, Ryan Flournoy.”
– David Heilman (Sports Gambling Podcast Network)
“I’m digging through the crates a bit, but Tyquan Thornton looks like a diamond in the rough heading into Week 6 against the Lions. Detroit uses man coverage on dropbacks at the fifth-highest rate in the league. Thornton leads all Chiefs pass catchers in win rate against man coverage (22.9%) and ranks second in yards per route run (2.33). If Patrick Mahomes has the time in the pocket, he should be able to connect on deep shots down the field to Thornton. He’s worth a look in deeper leagues and a great DFS play as well.”
– Kyle Zeigler (Fantasy In Frames)
Isaiah Bond (WR – CLE)
“Isaiah Bond. Kimani Vidal is probably a popular pick, so I’ll pivot to Bond. Pittsburgh is actually bottom 10 versus fantasy WRs in 2025, and the game script is likely pointing to CLE throwing as they play from behind. Bond is an explosive receiver with a growing role (55%+ of snaps in 3 straight games), and Cedric Tillman is on IR.”
– Kevin Roberts (The DFS Build)
Jake Tonges (TE – SF)
“I think Jake Tonges is a good sleeper start this week and will continue to be until George Kittle‘s return. While he does have a low floor, the TE position is always volatile. He had three touchdowns in just five games this year and 16 targets over the last two weeks. With one touchdown being enough to make him a solid TE play, Tonges has as good a chance as any to do that.”
– Trevor Land (FlurrySports)
Hassan Haskins (RB – LAC)
“The player outside of the top 100 in the FantasyPros flex rankings that is a good sleeper start this week is Hassan Haskins. I think he has upside this week because the Los Angeles Chargers just placed Omarion Hampton on injured reserve, leaving the RB room thin. Haskins is already on the roster and has better size for goal-line/short-yardage work than some alternatives. Miami’s run defense has been vulnerable, which could further boost his upside this week.”
– Jeff Boggis (Fantasy Football Empire)
“The Chargers’ injury crisis has devastated their running back corps, putting Kimani Vidal and Hassan Haskins in a battle for 15-20 touches per game, making both top Flex sleepers. However, Haskins gets my nod for this week because of his collegiate history with Jim Harbaugh. I have fired up the DeLorean for a trip to the future to solve the Chargers RB mystery. My prediction is that Haskins will be the starter who delivers a win for fantasy managers this week, but Vidal will take over the lead role until Hampton returns!”
– Luke Renton (The Franchise Tag UK)
Kimani Vidal (RB – LAC)
“Los Angeles Chargers running back Kimani Vidal is a strong sleeper start this week as a flex option, sitting well outside the top 100 in FantasyPros rankings. With Najee Harris sidelined for the season due to a torn Achilles and Omarion Hampton now on injured reserve with an ankle injury that will cost him at least four weeks, Vidal steps into a prominent role in a suddenly depleted backfield. He saw 14 snaps and had a modest stat line of four carries for 18 yards plus a reception in Week 5 after Hampton’s exit. Still, his superior speed and pass-catching ability over Hassan Haskins position him for more touches in a committee that could tilt his way. The Chargers face a Dolphins defense that’s middling against the run, giving Vidal real upside for 10-15 touches and a potential score if he earns goal-line work. As a rookie with explosive traits from Troy University, he’s a high-reward dice roll for desperate managers.”
– Aaron St Denis (Fantasy Sports Advice Network)
AJ Barner (TE – SEA)
“AJ Barner was supposed to be an afterthought when the Seahawks drafted Elijah Arroyo. Instead, he has taken the TE1 role for the team and posted top 9 finishes in three weeks so far (including TE #1 last week!). Even after that, he is still ranked TE21, which makes him a steal for owners who are paying attention to the waiver wire. Last week, he was targeted seven times. That should start to be a regular occurrence with Sam Darnold‘s confidence in the young tight end growing. Start him this week and for the rest of the season with confidence!”
– Adam Dove (The Fantasy Couriers)
Ryan Flournoy (WR – DAL)
“Ryan Flournoy had a breakout game for the Cowboys last week, and I think it continues Sunday. The second-year receiver almost matched his career yardage against the Jets, catching six of nine targets for 114 yards, with over a hundred in the first half alone. Dak Prescott is seeing defenses keying on George Pickens in CeeDee Lamb‘s absence, and Flournoy should continue to be the benefactor.”
– Michael Tomlin (Fantasy Six Pack)
Tory Horton (WR – SEA)
“While the floor is not great, Tory Horton has produced results through the first five games of his NFL career. Horton has three scores in his first five contests, something managers with potential bye week issues could be interested in. However, the downside with Horton is that he has not had a game with over 40 yards receiving thus far. Seattle may have to throw more this week against the Jaguars, making Horton an interesting dart throw in deeper leagues, even if it is very touchdown-or-bust.”
– Ed Birdsall (Talking Points Sports)
Theo Johnson (TE – NYG)
“Jaxson Dart is still a work in progress, but he’s focusing on his tight ends and backs when he does throw the ball. Theo Johnson’s touchdown equity is too big to ignore.”
– Scott Pianowski (Yahoo! Sports)
Duds
Which player inside the top 40 in the FantasyPros Flex rankings is likely to disappoint fantasy managers this week?
Derrick Henry (RB – BAL)
“Derrick Henry. Is anyone still trusting him? Godspeed if so, as Henry has failed to top (gulp) even 11 fantasy points in any of his last four games. Volume and falling into the endzone could always save him, but the Ravens are more predictable sans Lamar, and the Rams (3rd against fantasy RBs) are a nightmare spot.”- Kevin Roberts (The DFS Build)
“Baltimore Ravens running back Derrick Henry is poised to disappoint fantasy managers this week due to mounting challenges for the Ravens’ offense. The possibility of another missed game for quarterback Lamar Jackson, who has an “outside shot” at playing through his hamstring injury, would force backup Cooper Rush into a less dynamic role, limiting Henry’s receiving opportunities and overall volume. With the Ravens already at a dismal 1-4 record and facing a tough Los Angeles Rams defense, Baltimore could easily fall into a negative game script, forcing them to abandon the run early. Their injury woes compound the issue, as key defenders like safety Kyle Hamilton (shoulder), linebacker Roquan Smith (ankle), cornerback Marlon Humphrey (knee), and defensive tackle Nnamdi Madubuike (neck) are all sidelined, potentially allowing the Rams to build a lead and cap Henry’s touches at under 15 carries. Even against a middling Rams run defense, Henry’s recent inefficiency (averaging just 3.5 yards per carry without Jackson) signals low-upside production in this spot.”
– Aaron St Denis (Fantasy Sports Advice Network)
“Unfortunately, it has to be Derrick Henry, who’s likely to disappoint. With Lamar Jackson expected to miss the game with a hamstring injury and the Ravens on a Week 7 bye, it makes sense to sit him. Baltimore could get blown out at home again, this time by Stafford and the Rams. Henry salvaged his fantasy day last week against Houston with a touchdown, but averaged just 2.2 yards per carry. He also had only eight carries for 42 yards against the Chiefs in a game where Baltimore was trailing. King Henry can hit the bench with all the other peasants.”
– Kyle Zeigler (Fantasy In Frames)
“Sadly, it is Derrick Henry. If Lamar Jackson plays this week, it may be a different story; however, the Ravens with Cooper Rush at QB versus the Rams just screams no go. Teams can stack the box against Baltimore to focus solely on Henry without Jackson in the lineup, daring Cooper Rush to beat them over the top. As shown last week, it did not work out all that well. If Baltimore goes down, they will have to start throwing the ball, leaving Henry on the outside looking in, especially on passing downs. While Henry is a great buy right now with the team’s bye next week giving Baltimore a chance to get healthy, this isn’t the week we see The King go off.”
– Ed Birdsall (Talking Points Sports)
Garrett Wilson (WR – NYJ)
“Unfortunately, Garrett Wilson gets the Denver Broncos’ stingy defense this week. He should see a lot of Patrick Surtain, who last year matched up with Wilson for 25 routes (2 rec, 22 yards). Despite the production this season, this is a good enough reason to downgrade him this week.”
– Terrell Furman Jr. (FantasyPros)
“Garrett Wilson is the WR5 for the year, averaging 19 PPR fantasy points per game. However, most of his fantasy production comes in the fourth quarter when the New York Jets are chasing points in garbage time. The former Ohio State star has averaged 10.5 fantasy points per game over the first three quarters compared to 8.1 in the fourth. More importantly, Wilson faces an elite Denver Broncos defense early Sunday morning in London. They have held wide receivers to 27.7 fantasy points per game, the fifth-fewest in the NFL. Furthermore, the Broncos have surrendered only 4.8 receptions on 7.8 targets for 44.4 receiving yards and 9.2 fantasy points per game to opposing No. 1 wide receivers, allowing 9.3 or fewer in all but one contest despite facing A.J. Brown and Ja’Marr Chase the past two weeks. Unfortunately, Wilson will likely finish Week 6 outside the top 24 wide receivers.”
– Mike Fanelli (FantasyPros)
“I think that Garrett Wilson will disappoint fantasy managers in Week 6 due to a combination of matchup difficulty and offensive issues. The Jets face the Denver Broncos this week, an elite pass defense that is likely to deploy a premier shadow corner against him, drastically lowering his ceiling. Furthermore, the Jets’ offense is projected to have one of the lowest team totals of the week, with Justin Fields‘ play style limiting passing volume. These factors will result in a frustrating week for his owners.”
– Luke Renton (The Franchise Tag UK)
Cam Skattebo (RB – NYG)
“I know he’s a fun player, but Cam Skattebo is going to disappoint again. He struggled against the New Orleans Saints this past week and will face an even tougher defense in the Philadelphia Eagles this week. He’s always been touchdown dependent, but he’s going to be even more so this week as he’ll likely have trouble getting even 50 rushing yards this week.”
– Trevor Land (FlurrySports)
A.J. Brown (WR – PHI)
“A.J. Brown continues to get ranked on name recognition and upside. He is a boom-bust play that, unfortunately, has been a boom in only 20% of games this year. His good games are great, finishing WR3. His bad games could lose you the week, scoring less than 1 point in two games and a combined 8.5 points in his four bad games. He is 40th in the flex rankings as we speak, he won’t be inside my top-40.”
– David Heilman (Sports Gambling Podcast Network)
“A.J. Brown feels like a rinse and repeat answer here, just like I’ve been saying since the pre-season. Tre Tucker scored 3.5 PPR points less in Week 3 alone than Brown has all season. Outside of the Rams game, when the Eagles were trailing by three scores and had to throw non-stop, Brown is averaging three catches for 21 yards in the four other games. The Eagles were leading the majority of the time in all four of those games. What do you think will happen on a short week against the lowly Giants?”
– Michael Tomlin (Fantasy Six Pack)
Xavier Worthy (WR – KC)
“The player inside the top 40 in the FantasyPros flex rankings that is likely to disappoint fantasy managers this week is Xavier Worthy (WR-KC). His fantasy value is heavily tied to big plays, and he’s facing a defense built to eliminate those explosive passes. Opposing secondaries have been shading coverage his way since his breakout game, and his target share has dipped below 15% in two straight weeks. With Rashee Rice and Travis Kelce commanding the high-percentage routes and Patrick Mahomes spreading the ball around more, Worthy’s production becomes boom-or-bust—and this matchup profiles as a “bust” week. Expect limited volume, a low floor, and touchdown dependency against a defense that hasn’t allowed a 40+ yard reception all season.”
– Jeff Boggis (Fantasy Football Empire)
Drake London (WR – ATL)
“Drake London finally had a breakout in week 4 with 8/110/1 against the Commanders. That has moved him all the way up to WR4in half-PPR rankings. Drake London is a top-tier wide receiver, but that ranking could lead to disappointment for fantasy managers due to Michael Penix‘s inconsistency, and he is facing a Buffalo defense that is only allowing 154 yards/game. He should maintain a high target share; however, owners should lower expectations for London Week 6, but get excited for some upcoming weeks against weaker defenses.”
– Adam Dove (The Fantasy Couriers)
Ja’Marr Chase (WR – CIN)
“If you wanted to get out of the Ja’Marr Chase business, Week 5’s splash game gives you a chance. No mat£ter who takes the QB snaps this week, Cincinnati is likely to get thumped by a rested Green Bay team and defense.”
– Scott Pianowski (Yahoo! Sports)
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