| Week 1 | Jacksonville Jaguars vs. Indianapolis Colts | Sunday, September 10th, 2023 at 1:00pm ET |
| Week 2 | Indianapolis Colts vs. Houston Texans | Sunday, September 17th, 2023 at 1:00pm ET |
| Week 3 | Indianapolis Colts vs. Baltimore Ravens | Sunday, September 24th, 2023 at 1:00pm ET |
| Week 4 | Los Angeles Rams vs. Indianapolis Colts | Sunday, October 1st, 2023 at 1:00pm ET |
| Week 5 | Tennessee Titans vs. Indianapolis Colts | Sunday, October 8th, 2023 at 1:00pm ET |
| Week 6 | Indianapolis Colts vs. Jacksonville Jaguars | Sunday, October 15th, 2023 at 1:00pm ET |
| Week 7 | Cleveland Browns vs. Indianapolis Colts | Sunday, October 22nd, 2023 at 1:00pm ET |
| Week 8 | New Orleans Saints vs. Indianapolis Colts | Sunday, October 29th, 2023 at 1:00pm ET |
| Week 9 | Indianapolis Colts vs. Carolina Panthers | Sunday, November 5th, 2023 at 4:05pm ET |
| Week 10 | Indianapolis Colts vs. New England Patriots | Sunday, November 12th, 2023 at 9:30am ET |
| Week 11 | Bye Week | |
| Week 12 | Tampa Bay Buccaneers vs. Indianapolis Colts | Sunday, November 26th, 2023 at 1:00pm ET |
| Week 13 | Indianapolis Colts vs. Tennessee Titans | Sunday, December 3rd, 2023 at 1:00pm ET |
| Week 14 | Indianapolis Colts vs. Cincinnati Bengals | Sunday, December 10th, 2023 at 1:00pm ET |
| Week 15 | Pittsburgh Steelers vs. Indianapolis Colts | Saturday, December 16th, 2023 at 4:30pm ET |
| Week 16 | Indianapolis Colts vs. Atlanta Falcons | Sunday, December 24th, 2023 at 1:00pm ET |
| Week 17 | Las Vegas Raiders vs. Indianapolis Colts | Sunday, December 31st, 2023 at 1:00pm ET |
| Week 18 | Houston Texans vs. Indianapolis Colts | Saturday, January 6th, 2024 at 8:15pm ET |
