| Week 1 | Buffalo Bills vs. Houston Texans | Sunday, September 13th, 2026 at 1:00pm ET |
| Week 2 | Cincinnati Bengals vs. Houston Texans | Sunday, September 20th, 2026 at 1:00pm ET |
| Week 3 | Houston Texans vs. Indianapolis Colts | Sunday, September 27th, 2026 at 1:00pm ET |
| Week 4 | Dallas Cowboys vs. Houston Texans | Sunday, October 4th, 2026 at 1:00pm ET |
| Week 5 | Houston Texans vs. Tennessee Titans | Sunday, October 11th, 2026 at 1:00pm ET |
| Week 6 | Houston Texans vs. Jacksonville Jaguars | Sunday, October 18th, 2026 at 9:30am ET |
| Week 7 | New York Giants vs. Houston Texans | Sunday, October 25th, 2026 at 1:00pm ET |
| Week 8 | Bye Week | |
| Week 9 | Houston Texans vs. Los Angeles Chargers | Sunday, November 8th, 2026 at 4:05pm ET |
| Week 10 | Houston Texans vs. Cleveland Browns | Sunday, November 15th, 2026 at 1:00pm ET |
| Week 11 | Indianapolis Colts vs. Houston Texans | Thursday, November 19th, 2026 at 8:15pm ET |
| Week 12 | Baltimore Ravens vs. Houston Texans | Sunday, November 29th, 2026 at 1:00pm ET |
| Week 13 | Houston Texans vs. Pittsburgh Steelers | Sunday, December 6th, 2026 at 8:20pm ET |
| Week 14 | Houston Texans vs. Washington Commanders | Sunday, December 13th, 2026 at 1:00pm ET |
| Week 15 | Jacksonville Jaguars vs. Houston Texans | Sunday, December 20th, 2026 at 1:00pm ET |
| Week 16 | Houston Texans vs. Philadelphia Eagles | Thursday, December 24th, 2026 at 8:15pm ET |
| Week 17 | Houston Texans vs. Green Bay Packers | Monday, January 4th, 2027 at 8:15pm ET |
| Week 18 | Tennessee Titans vs. Houston Texans | Sunday, January 10th, 2027 at 1:00pm ET |
