| Week 1 | Houston Texans vs. Los Angeles Rams | Sunday, September 7th, 2025 at 4:25pm ET |
| Week 2 | Tampa Bay Buccaneers vs. Houston Texans | Monday, September 15th, 2025 at 7:00pm ET |
| Week 3 | Houston Texans vs. Jacksonville Jaguars | Sunday, September 21st, 2025 at 1:00pm ET |
| Week 4 | Tennessee Titans vs. Houston Texans | Sunday, September 28th, 2025 at 1:00pm ET |
| Week 5 | Houston Texans vs. Baltimore Ravens | Sunday, October 5th, 2025 at 1:00pm ET |
| Week 6 | Bye Week | |
| Week 7 | Houston Texans vs. Seattle Seahawks | Monday, October 20th, 2025 at 10:00pm ET |
| Week 8 | San Francisco 49ers vs. Houston Texans | Sunday, October 26th, 2025 at 1:00pm ET |
| Week 9 | Denver Broncos vs. Houston Texans | Sunday, November 2nd, 2025 at 1:00pm ET |
| Week 10 | Jacksonville Jaguars vs. Houston Texans | Sunday, November 9th, 2025 at 1:00pm ET |
| Week 11 | Houston Texans vs. Tennessee Titans | Sunday, November 16th, 2025 at 1:00pm ET |
| Week 12 | Buffalo Bills vs. Houston Texans | Thursday, November 20th, 2025 at 8:15pm ET |
| Week 13 | Houston Texans vs. Indianapolis Colts | Sunday, November 30th, 2025 at 1:00pm ET |
| Week 14 | Houston Texans vs. Kansas City Chiefs | Sunday, December 7th, 2025 at 8:20pm ET |
| Week 15 | Arizona Cardinals vs. Houston Texans | Sunday, December 14th, 2025 at 1:00pm ET |
| Week 16 | Las Vegas Raiders vs. Houston Texans | Sunday, December 21st, 2025 at 4:25pm ET |
| Week 17 | Houston Texans vs. Los Angeles Chargers | Sunday, December 28th, 2025 at 1:00pm ET |
| Week 18 | Indianapolis Colts vs. Houston Texans | Sunday, January 4th, 2026 at 1:00pm ET |
