| Week 1 | Houston Texans vs. Baltimore Ravens | Sunday, September 10th, 2023 at 1:00pm ET |
| Week 2 | Indianapolis Colts vs. Houston Texans | Sunday, September 17th, 2023 at 1:00pm ET |
| Week 3 | Houston Texans vs. Jacksonville Jaguars | Sunday, September 24th, 2023 at 1:00pm ET |
| Week 4 | Pittsburgh Steelers vs. Houston Texans | Sunday, October 1st, 2023 at 1:00pm ET |
| Week 5 | Houston Texans vs. Atlanta Falcons | Sunday, October 8th, 2023 at 1:00pm ET |
| Week 6 | New Orleans Saints vs. Houston Texans | Sunday, October 15th, 2023 at 1:00pm ET |
| Week 7 | Bye Week | |
| Week 8 | Houston Texans vs. Carolina Panthers | Sunday, October 29th, 2023 at 1:00pm ET |
| Week 9 | Tampa Bay Buccaneers vs. Houston Texans | Sunday, November 5th, 2023 at 1:00pm ET |
| Week 10 | Houston Texans vs. Cincinnati Bengals | Sunday, November 12th, 2023 at 1:00pm ET |
| Week 11 | Arizona Cardinals vs. Houston Texans | Sunday, November 19th, 2023 at 1:00pm ET |
| Week 12 | Jacksonville Jaguars vs. Houston Texans | Sunday, November 26th, 2023 at 1:00pm ET |
| Week 13 | Denver Broncos vs. Houston Texans | Sunday, December 3rd, 2023 at 1:00pm ET |
| Week 14 | Houston Texans vs. New York Jets | Sunday, December 10th, 2023 at 1:00pm ET |
| Week 15 | Houston Texans vs. Tennessee Titans | Sunday, December 17th, 2023 at 1:00pm ET |
| Week 16 | Cleveland Browns vs. Houston Texans | Sunday, December 24th, 2023 at 1:00pm ET |
| Week 17 | Tennessee Titans vs. Houston Texans | Sunday, December 31st, 2023 at 1:00pm ET |
| Week 18 | Houston Texans vs. Indianapolis Colts | Sunday, January 7th, 2024 at 1:00pm ET |
