| Week 1 | Arizona Cardinals vs. New Orleans Saints | Sunday, September 7th, 2025 at 1:00pm ET |
| Week 2 | Carolina Panthers vs. Arizona Cardinals | Sunday, September 14th, 2025 at 4:05pm ET |
| Week 3 | Arizona Cardinals vs. San Francisco 49ers | Sunday, September 21st, 2025 at 4:25pm ET |
| Week 4 | Seattle Seahawks vs. Arizona Cardinals | Thursday, September 25th, 2025 at 8:15pm ET |
| Week 5 | Tennessee Titans vs. Arizona Cardinals | Sunday, October 5th, 2025 at 4:05pm ET |
| Week 6 | Arizona Cardinals vs. Indianapolis Colts | Sunday, October 12th, 2025 at 1:00pm ET |
| Week 7 | Green Bay Packers vs. Arizona Cardinals | Sunday, October 19th, 2025 at 4:25pm ET |
| Week 8 | Bye Week | |
| Week 9 | Arizona Cardinals vs. Dallas Cowboys | Monday, November 3rd, 2025 at 8:15pm ET |
| Week 10 | Arizona Cardinals vs. Seattle Seahawks | Sunday, November 9th, 2025 at 4:05pm ET |
| Week 11 | San Francisco 49ers vs. Arizona Cardinals | Sunday, November 16th, 2025 at 4:05pm ET |
| Week 12 | Jacksonville Jaguars vs. Arizona Cardinals | Sunday, November 23rd, 2025 at 4:05pm ET |
| Week 13 | Arizona Cardinals vs. Tampa Bay Buccaneers | Sunday, November 30th, 2025 at 1:00pm ET |
| Week 14 | Los Angeles Rams vs. Arizona Cardinals | Sunday, December 7th, 2025 at 4:25pm ET |
| Week 15 | Arizona Cardinals vs. Houston Texans | Sunday, December 14th, 2025 at 1:00pm ET |
| Week 16 | Atlanta Falcons vs. Arizona Cardinals | Sunday, December 21st, 2025 at 4:05pm ET |
| Week 17 | Arizona Cardinals vs. Cincinnati Bengals | Sunday, December 28th, 2025 at 1:00pm ET |
| Week 18 | Arizona Cardinals vs. Los Angeles Rams | Sunday, January 4th, 2026 at 1:00pm ET |
