| Week 1 | Arizona Cardinals vs. San Francisco 49ers | Sunday, September 13th, 2020 at 4:25pm ET |
| Week 2 | Washington Football Team vs. Arizona Cardinals | Sunday, September 20th, 2020 at 4:05pm ET |
| Week 3 | Detroit Lions vs. Arizona Cardinals | Sunday, September 27th, 2020 at 4:25pm ET |
| Week 4 | Arizona Cardinals vs. Carolina Panthers | Sunday, October 4th, 2020 at 1:00pm ET |
| Week 5 | Arizona Cardinals vs. New York Jets | Sunday, October 11th, 2020 at 1:00pm ET |
| Week 6 | Arizona Cardinals vs. Dallas Cowboys | Monday, October 19th, 2020 at 8:15pm ET |
| Week 7 | Seattle Seahawks vs. Arizona Cardinals | Sunday, October 25th, 2020 at 4:05pm ET |
| Week 8 | Bye Week |
| Week 9 | Miami Dolphins vs. Arizona Cardinals | Sunday, November 8th, 2020 at 4:25pm ET |
| Week 10 | Buffalo Bills vs. Arizona Cardinals | Sunday, November 15th, 2020 at 4:05pm ET |
| Week 11 | Arizona Cardinals vs. Seattle Seahawks | Thursday, November 19th, 2020 at 8:20pm ET |
| Week 12 | Arizona Cardinals vs. New England Patriots | Sunday, November 29th, 2020 at 1:00pm ET |
| Week 13 | Los Angeles Rams vs. Arizona Cardinals | Sunday, December 6th, 2020 at 4:05pm ET |
| Week 14 | Arizona Cardinals vs. New York Giants | Sunday, December 13th, 2020 at 1:00pm ET |
| Week 15 | Philadelphia Eagles vs. Arizona Cardinals | Sunday, December 20th, 2020 at 4:05pm ET |
| Week 16 | San Francisco 49ers vs. Arizona Cardinals | Sunday, December 27th, 2020 at 1:00am ET |
| Week 17 | Arizona Cardinals vs. Los Angeles Rams | Sunday, January 3rd, 2021 at 4:25pm ET |
