| Week 1 | Detroit Lions vs. Arizona Cardinals | Sunday, September 8th, 2019 at 4:25pm ET |
| Week 2 | Arizona Cardinals vs. Baltimore Ravens | Sunday, September 15th, 2019 at 1:00pm ET |
| Week 3 | Carolina Panthers vs. Arizona Cardinals | Sunday, September 22nd, 2019 at 4:05pm ET |
| Week 4 | Seattle Seahawks vs. Arizona Cardinals | Sunday, September 29th, 2019 at 4:05pm ET |
| Week 5 | Arizona Cardinals vs. Cincinnati Bengals | Sunday, October 6th, 2019 at 1:00pm ET |
| Week 6 | Atlanta Falcons vs. Arizona Cardinals | Sunday, October 13th, 2019 at 4:05pm ET |
| Week 7 | Arizona Cardinals vs. New York Giants | Sunday, October 20th, 2019 at 1:00pm ET |
| Week 8 | Arizona Cardinals vs. New Orleans Saints | Sunday, October 27th, 2019 at 1:00pm ET |
| Week 9 | San Francisco 49ers vs. Arizona Cardinals | Thursday, October 31st, 2019 at 8:20pm ET |
| Week 10 | Arizona Cardinals vs. Tampa Bay Buccaneers | Sunday, November 10th, 2019 at 1:00pm ET |
| Week 11 | Arizona Cardinals vs. San Francisco 49ers | Sunday, November 17th, 2019 at 4:05pm ET |
| Week 12 | Bye Week |
| Week 13 | Los Angeles Rams vs. Arizona Cardinals | Sunday, December 1st, 2019 at 4:05pm ET |
| Week 14 | Pittsburgh Steelers vs. Arizona Cardinals | Sunday, December 8th, 2019 at 4:25pm ET |
| Week 15 | Cleveland Browns vs. Arizona Cardinals | Sunday, December 15th, 2019 at 4:05pm ET |
| Week 16 | Arizona Cardinals vs. Seattle Seahawks | Sunday, December 22nd, 2019 at 4:25pm ET |
| Week 17 | Arizona Cardinals vs. Los Angeles Rams | Sunday, December 29th, 2019 at 4:25pm ET |
