| Week 1 | Buffalo Bills vs. Houston Texans | Sunday, September 13th, 2026 at 1:00pm ET |
| Week 2 | Detroit Lions vs. Buffalo Bills | Thursday, September 17th, 2026 at 8:15pm ET |
| Week 3 | Los Angeles Chargers vs. Buffalo Bills | Sunday, September 27th, 2026 at 1:00pm ET |
| Week 4 | New England Patriots vs. Buffalo Bills | Sunday, October 4th, 2026 at 1:00pm ET |
| Week 5 | Buffalo Bills vs. Los Angeles Rams | Monday, October 12th, 2026 at 8:15pm ET |
| Week 6 | Buffalo Bills vs. Las Vegas Raiders | Sunday, October 18th, 2026 at 4:25pm ET |
| Week 7 | Bye Week | |
| Week 8 | Baltimore Ravens vs. Buffalo Bills | Sunday, November 1st, 2026 at 1:00pm ET |
| Week 9 | Buffalo Bills vs. Minnesota Vikings | Monday, November 9th, 2026 at 8:15pm ET |
| Week 10 | Buffalo Bills vs. New York Jets | Sunday, November 15th, 2026 at 1:00pm ET |
| Week 11 | Miami Dolphins vs. Buffalo Bills | Sunday, November 22nd, 2026 at 1:00pm ET |
| Week 12 | Kansas City Chiefs vs. Buffalo Bills | Thursday, November 26th, 2026 at 8:20pm ET |
| Week 13 | Buffalo Bills vs. New England Patriots | Sunday, December 6th, 2026 at 4:25pm ET |
| Week 14 | Buffalo Bills vs. Green Bay Packers | Sunday, December 13th, 2026 at 8:20pm ET |
| Week 15 | Chicago Bears vs. Buffalo Bills | Saturday, December 19th, 2026 at 8:20pm ET |
| Week 16 | Buffalo Bills vs. Denver Broncos | Friday, December 25th, 2026 at 4:30pm ET |
| Week 17 | Buffalo Bills vs. Miami Dolphins | Sunday, January 3rd, 2027 at 1:00pm ET |
| Week 18 | New York Jets vs. Buffalo Bills | Sunday, January 10th, 2027 at 1:00pm ET |
