| Week 1 | Buffalo Bills vs. New York Jets | Monday, September 11th, 2023 at 8:15pm ET |
| Week 2 | Las Vegas Raiders vs. Buffalo Bills | Sunday, September 17th, 2023 at 1:00pm ET |
| Week 3 | Buffalo Bills vs. Washington Commanders | Sunday, September 24th, 2023 at 1:00pm ET |
| Week 4 | Miami Dolphins vs. Buffalo Bills | Sunday, October 1st, 2023 at 1:00pm ET |
| Week 5 | Jacksonville Jaguars vs. Buffalo Bills | Sunday, October 8th, 2023 at 9:30am ET |
| Week 6 | New York Giants vs. Buffalo Bills | Sunday, October 15th, 2023 at 8:20pm ET |
| Week 7 | Buffalo Bills vs. New England Patriots | Sunday, October 22nd, 2023 at 1:00pm ET |
| Week 8 | Tampa Bay Buccaneers vs. Buffalo Bills | Thursday, October 26th, 2023 at 8:15pm ET |
| Week 9 | Buffalo Bills vs. Cincinnati Bengals | Sunday, November 5th, 2023 at 8:20pm ET |
| Week 10 | Denver Broncos vs. Buffalo Bills | Monday, November 13th, 2023 at 8:15pm ET |
| Week 11 | New York Jets vs. Buffalo Bills | Sunday, November 19th, 2023 at 4:25pm ET |
| Week 12 | Buffalo Bills vs. Philadelphia Eagles | Sunday, November 26th, 2023 at 4:25pm ET |
| Week 13 | Bye Week | |
| Week 14 | Buffalo Bills vs. Kansas City Chiefs | Sunday, December 10th, 2023 at 4:25pm ET |
| Week 15 | Dallas Cowboys vs. Buffalo Bills | Sunday, December 17th, 2023 at 4:25pm ET |
| Week 16 | Buffalo Bills vs. Los Angeles Chargers | Saturday, December 23rd, 2023 at 8:00pm ET |
| Week 17 | New England Patriots vs. Buffalo Bills | Sunday, December 31st, 2023 at 1:00pm ET |
| Week 18 | Buffalo Bills vs. Miami Dolphins | Sunday, January 7th, 2024 at 8:20pm ET |
