| Week 1 | Minnesota Vikings vs. Chicago Bears | Monday, September 8th, 2025 at 8:15pm ET |
| Week 2 | Chicago Bears vs. Detroit Lions | Sunday, September 14th, 2025 at 1:00pm ET |
| Week 3 | Dallas Cowboys vs. Chicago Bears | Sunday, September 21st, 2025 at 4:25pm ET |
| Week 4 | Chicago Bears vs. Las Vegas Raiders | Sunday, September 28th, 2025 at 4:25pm ET |
| Week 5 | Bye Week | |
| Week 6 | Chicago Bears vs. Washington Commanders | Monday, October 13th, 2025 at 8:15pm ET |
| Week 7 | New Orleans Saints vs. Chicago Bears | Sunday, October 19th, 2025 at 1:00pm ET |
| Week 8 | Chicago Bears vs. Baltimore Ravens | Sunday, October 26th, 2025 at 1:00pm ET |
| Week 9 | Chicago Bears vs. Cincinnati Bengals | Sunday, November 2nd, 2025 at 1:00pm ET |
| Week 10 | New York Giants vs. Chicago Bears | Sunday, November 9th, 2025 at 1:00pm ET |
| Week 11 | Chicago Bears vs. Minnesota Vikings | Sunday, November 16th, 2025 at 1:00pm ET |
| Week 12 | Pittsburgh Steelers vs. Chicago Bears | Sunday, November 23rd, 2025 at 1:00pm ET |
| Week 13 | Chicago Bears vs. Philadelphia Eagles | Friday, November 28th, 2025 at 3:00pm ET |
| Week 14 | Chicago Bears vs. Green Bay Packers | Sunday, December 7th, 2025 at 4:25pm ET |
| Week 15 | Cleveland Browns vs. Chicago Bears | Sunday, December 14th, 2025 at 1:00pm ET |
| Week 16 | Green Bay Packers vs. Chicago Bears | Saturday, December 20th, 2025 at 8:20pm ET |
| Week 17 | Chicago Bears vs. San Francisco 49ers | Sunday, December 28th, 2025 at 8:20pm ET |
| Week 18 | Detroit Lions vs. Chicago Bears | Sunday, January 4th, 2026 at 1:00pm ET |
