| Week 1 | Cleveland Browns vs. Carolina Panthers | Sunday, September 11th, 2022 at 1:00pm ET |
| Week 2 | New York Jets vs. Cleveland Browns | Sunday, September 18th, 2022 at 1:00pm ET |
| Week 3 | Pittsburgh Steelers vs. Cleveland Browns | Thursday, September 22nd, 2022 at 8:15pm ET |
| Week 4 | Cleveland Browns vs. Atlanta Falcons | Sunday, October 2nd, 2022 at 1:00pm ET |
| Week 5 | Los Angeles Chargers vs. Cleveland Browns | Sunday, October 9th, 2022 at 1:00pm ET |
| Week 6 | New England Patriots vs. Cleveland Browns | Sunday, October 16th, 2022 at 1:00pm ET |
| Week 7 | Cleveland Browns vs. Baltimore Ravens | Sunday, October 23rd, 2022 at 1:00pm ET |
| Week 8 | Cincinnati Bengals vs. Cleveland Browns | Monday, October 31st, 2022 at 8:15pm ET |
| Week 9 | Bye Week | |
| Week 10 | Cleveland Browns vs. Miami Dolphins | Sunday, November 13th, 2022 at 1:00pm ET |
| Week 11 | Cleveland Browns vs. Buffalo Bills | Sunday, November 20th, 2022 at 1:00pm ET |
| Week 12 | Tampa Bay Buccaneers vs. Cleveland Browns | Sunday, November 27th, 2022 at 1:00pm ET |
| Week 13 | Cleveland Browns vs. Houston Texans | Sunday, December 4th, 2022 at 1:00pm ET |
| Week 14 | Cleveland Browns vs. Cincinnati Bengals | Sunday, December 11th, 2022 at 1:00pm ET |
| Week 15 | Baltimore Ravens vs. Cleveland Browns | Sunday, December 18th, 2022 at 1:00pm ET |
| Week 16 | New Orleans Saints vs. Cleveland Browns | Saturday, December 24th, 2022 at 1:00pm ET |
| Week 17 | Cleveland Browns vs. Washington Commanders | Sunday, January 1st, 2023 at 1:00pm ET |
| Week 18 | Cleveland Browns vs. Pittsburgh Steelers | Sunday, January 8th, 2023 at 1:00pm ET |
