| Week 1 | Cleveland Browns vs. Baltimore Ravens | Sunday, September 13th, 2020 at 1:00pm ET |
| Week 2 | Cincinnati Bengals vs. Cleveland Browns | Thursday, September 17th, 2020 at 8:20pm ET |
| Week 3 | Washington Football Team vs. Cleveland Browns | Sunday, September 27th, 2020 at 1:00pm ET |
| Week 4 | Cleveland Browns vs. Dallas Cowboys | Sunday, October 4th, 2020 at 1:00pm ET |
| Week 5 | Indianapolis Colts vs. Cleveland Browns | Sunday, October 11th, 2020 at 4:25pm ET |
| Week 6 | Cleveland Browns vs. Pittsburgh Steelers | Sunday, October 18th, 2020 at 1:00pm ET |
| Week 7 | Cleveland Browns vs. Cincinnati Bengals | Sunday, October 25th, 2020 at 1:00pm ET |
| Week 8 | Las Vegas Raiders vs. Cleveland Browns | Sunday, November 1st, 2020 at 1:00pm ET |
| Week 9 | Bye Week |
| Week 10 | Houston Texans vs. Cleveland Browns | Sunday, November 15th, 2020 at 1:00pm ET |
| Week 11 | Philadelphia Eagles vs. Cleveland Browns | Sunday, November 22nd, 2020 at 1:00pm ET |
| Week 12 | Cleveland Browns vs. Jacksonville Jaguars | Sunday, November 29th, 2020 at 1:00pm ET |
| Week 13 | Cleveland Browns vs. Tennessee Titans | Sunday, December 6th, 2020 at 1:00pm ET |
| Week 14 | Baltimore Ravens vs. Cleveland Browns | Monday, December 14th, 2020 at 8:15pm ET |
| Week 15 | Cleveland Browns vs. New York Giants | Sunday, December 20th, 2020 at 1:00pm ET |
| Week 16 | Cleveland Browns vs. New York Jets | Sunday, December 27th, 2020 at 1:00pm ET |
| Week 17 | Pittsburgh Steelers vs. Cleveland Browns | Sunday, January 3rd, 2021 at 1:00pm ET |
