| Week 1 | Tennessee Titans vs. Cleveland Browns | Sunday, September 8th, 2019 at 1:00pm ET |
| Week 2 | Cleveland Browns vs. New York Jets | Monday, September 16th, 2019 at 8:15pm ET |
| Week 3 | Los Angeles Rams vs. Cleveland Browns | Sunday, September 22nd, 2019 at 8:20pm ET |
| Week 4 | Cleveland Browns vs. Baltimore Ravens | Sunday, September 29th, 2019 at 1:00pm ET |
| Week 5 | Cleveland Browns vs. San Francisco 49ers | Monday, October 7th, 2019 at 8:15pm ET |
| Week 6 | Seattle Seahawks vs. Cleveland Browns | Sunday, October 13th, 2019 at 1:00pm ET |
| Week 7 | Bye Week |
| Week 8 | Cleveland Browns vs. New England Patriots | Sunday, October 27th, 2019 at 4:25pm ET |
| Week 9 | Cleveland Browns vs. Denver Broncos | Sunday, November 3rd, 2019 at 4:25pm ET |
| Week 10 | Buffalo Bills vs. Cleveland Browns | Sunday, November 10th, 2019 at 1:00pm ET |
| Week 11 | Pittsburgh Steelers vs. Cleveland Browns | Thursday, November 14th, 2019 at 8:20pm ET |
| Week 12 | Miami Dolphins vs. Cleveland Browns | Sunday, November 24th, 2019 at 1:00pm ET |
| Week 13 | Cleveland Browns vs. Pittsburgh Steelers | Sunday, December 1st, 2019 at 4:25pm ET |
| Week 14 | Cincinnati Bengals vs. Cleveland Browns | Sunday, December 8th, 2019 at 1:00pm ET |
| Week 15 | Cleveland Browns vs. Arizona Cardinals | Sunday, December 15th, 2019 at 4:05pm ET |
| Week 16 | Baltimore Ravens vs. Cleveland Browns | Sunday, December 22nd, 2019 at 1:00pm ET |
| Week 17 | Cleveland Browns vs. Cincinnati Bengals | Sunday, December 29th, 2019 at 1:00pm ET |
