| Week 1 | Cincinnati Bengals vs. Cleveland Browns | Sunday, September 7th, 2025 at 1:00pm ET |
| Week 2 | Cleveland Browns vs. Baltimore Ravens | Sunday, September 14th, 2025 at 1:00pm ET |
| Week 3 | Green Bay Packers vs. Cleveland Browns | Sunday, September 21st, 2025 at 1:00pm ET |
| Week 4 | Cleveland Browns vs. Detroit Lions | Sunday, September 28th, 2025 at 1:00pm ET |
| Week 5 | Minnesota Vikings vs. Cleveland Browns | Sunday, October 5th, 2025 at 9:30am ET |
| Week 6 | Cleveland Browns vs. Pittsburgh Steelers | Sunday, October 12th, 2025 at 1:00pm ET |
| Week 7 | Miami Dolphins vs. Cleveland Browns | Sunday, October 19th, 2025 at 1:00pm ET |
| Week 8 | Cleveland Browns vs. New England Patriots | Sunday, October 26th, 2025 at 1:00pm ET |
| Week 9 | Bye Week | |
| Week 10 | Cleveland Browns vs. New York Jets | Sunday, November 9th, 2025 at 1:00pm ET |
| Week 11 | Baltimore Ravens vs. Cleveland Browns | Sunday, November 16th, 2025 at 4:25pm ET |
| Week 12 | Cleveland Browns vs. Las Vegas Raiders | Sunday, November 23rd, 2025 at 4:05pm ET |
| Week 13 | San Francisco 49ers vs. Cleveland Browns | Sunday, November 30th, 2025 at 1:00pm ET |
| Week 14 | Tennessee Titans vs. Cleveland Browns | Sunday, December 7th, 2025 at 1:00pm ET |
| Week 15 | Cleveland Browns vs. Chicago Bears | Sunday, December 14th, 2025 at 1:00pm ET |
| Week 16 | Buffalo Bills vs. Cleveland Browns | Sunday, December 21st, 2025 at 1:00pm ET |
| Week 17 | Pittsburgh Steelers vs. Cleveland Browns | Sunday, December 28th, 2025 at 1:00pm ET |
| Week 18 | Cleveland Browns vs. Cincinnati Bengals | Sunday, January 4th, 2026 at 1:00pm ET |
