| Week 1 | Tennessee Titans vs. Denver Broncos | Sunday, September 7th, 2025 at 4:05pm ET |
| Week 2 | Denver Broncos vs. Indianapolis Colts | Sunday, September 14th, 2025 at 4:05pm ET |
| Week 3 | Denver Broncos vs. Los Angeles Chargers | Sunday, September 21st, 2025 at 4:05pm ET |
| Week 4 | Cincinnati Bengals vs. Denver Broncos | Monday, September 29th, 2025 at 8:15pm ET |
| Week 5 | Denver Broncos vs. Philadelphia Eagles | Sunday, October 5th, 2025 at 1:00pm ET |
| Week 6 | Denver Broncos vs. New York Jets | Sunday, October 12th, 2025 at 9:30am ET |
| Week 7 | New York Giants vs. Denver Broncos | Sunday, October 19th, 2025 at 4:05pm ET |
| Week 8 | Dallas Cowboys vs. Denver Broncos | Sunday, October 26th, 2025 at 4:25pm ET |
| Week 9 | Denver Broncos vs. Houston Texans | Sunday, November 2nd, 2025 at 1:00pm ET |
| Week 10 | Las Vegas Raiders vs. Denver Broncos | Thursday, November 6th, 2025 at 8:15pm ET |
| Week 11 | Kansas City Chiefs vs. Denver Broncos | Sunday, November 16th, 2025 at 4:25pm ET |
| Week 12 | Bye Week | |
| Week 13 | Denver Broncos vs. Washington Commanders | Sunday, November 30th, 2025 at 8:20pm ET |
| Week 14 | Denver Broncos vs. Las Vegas Raiders | Sunday, December 7th, 2025 at 4:05pm ET |
| Week 15 | Green Bay Packers vs. Denver Broncos | Sunday, December 14th, 2025 at 4:25pm ET |
| Week 16 | Jacksonville Jaguars vs. Denver Broncos | Sunday, December 21st, 2025 at 4:05pm ET |
| Week 17 | Denver Broncos vs. Kansas City Chiefs | Thursday, December 25th, 2025 at 8:15pm ET |
| Week 18 | Los Angeles Chargers vs. Denver Broncos | Sunday, January 4th, 2026 at 1:00pm ET |
