| Week 1 | Las Vegas Raiders vs. Los Angeles Chargers | Sunday, September 11th, 2022 at 4:25pm ET |
| Week 2 | Arizona Cardinals vs. Las Vegas Raiders | Sunday, September 18th, 2022 at 4:25pm ET |
| Week 3 | Las Vegas Raiders vs. Tennessee Titans | Sunday, September 25th, 2022 at 1:00pm ET |
| Week 4 | Denver Broncos vs. Las Vegas Raiders | Sunday, October 2nd, 2022 at 4:25pm ET |
| Week 5 | Las Vegas Raiders vs. Kansas City Chiefs | Monday, October 10th, 2022 at 8:15pm ET |
| Week 6 | Bye Week | |
| Week 7 | Houston Texans vs. Las Vegas Raiders | Sunday, October 23rd, 2022 at 4:05pm ET |
| Week 8 | Las Vegas Raiders vs. New Orleans Saints | Sunday, October 30th, 2022 at 1:00pm ET |
| Week 9 | Las Vegas Raiders vs. Jacksonville Jaguars | Sunday, November 6th, 2022 at 1:00pm ET |
| Week 10 | Indianapolis Colts vs. Las Vegas Raiders | Sunday, November 13th, 2022 at 4:05pm ET |
| Week 11 | Las Vegas Raiders vs. Denver Broncos | Sunday, November 20th, 2022 at 4:05pm ET |
| Week 12 | Las Vegas Raiders vs. Seattle Seahawks | Sunday, November 27th, 2022 at 4:05pm ET |
| Week 13 | Los Angeles Chargers vs. Las Vegas Raiders | Sunday, December 4th, 2022 at 4:25pm ET |
| Week 14 | Las Vegas Raiders vs. Los Angeles Rams | Thursday, December 8th, 2022 at 8:15pm ET |
| Week 15 | New England Patriots vs. Las Vegas Raiders | Sunday, December 18th, 2022 at 4:05pm ET |
| Week 16 | Las Vegas Raiders vs. Pittsburgh Steelers | Saturday, December 24th, 2022 at 8:15pm ET |
| Week 17 | San Francisco 49ers vs. Las Vegas Raiders | Sunday, January 1st, 2023 at 4:05pm ET |
| Week 18 | Kansas City Chiefs vs. Las Vegas Raiders | Saturday, January 7th, 2023 at 4:30pm ET |
