| Week 1 | Las Vegas Raiders vs. New England Patriots | Sunday, September 7th, 2025 at 1:00pm ET |
| Week 2 | Los Angeles Chargers vs. Las Vegas Raiders | Monday, September 15th, 2025 at 10:00pm ET |
| Week 3 | Las Vegas Raiders vs. Washington Commanders | Sunday, September 21st, 2025 at 1:00pm ET |
| Week 4 | Chicago Bears vs. Las Vegas Raiders | Sunday, September 28th, 2025 at 4:25pm ET |
| Week 5 | Las Vegas Raiders vs. Indianapolis Colts | Sunday, October 5th, 2025 at 1:00pm ET |
| Week 6 | Tennessee Titans vs. Las Vegas Raiders | Sunday, October 12th, 2025 at 4:05pm ET |
| Week 7 | Las Vegas Raiders vs. Kansas City Chiefs | Sunday, October 19th, 2025 at 1:00pm ET |
| Week 8 | Bye Week | |
| Week 9 | Jacksonville Jaguars vs. Las Vegas Raiders | Sunday, November 2nd, 2025 at 4:05pm ET |
| Week 10 | Las Vegas Raiders vs. Denver Broncos | Thursday, November 6th, 2025 at 8:15pm ET |
| Week 11 | Dallas Cowboys vs. Las Vegas Raiders | Monday, November 17th, 2025 at 8:15pm ET |
| Week 12 | Cleveland Browns vs. Las Vegas Raiders | Sunday, November 23rd, 2025 at 4:05pm ET |
| Week 13 | Las Vegas Raiders vs. Los Angeles Chargers | Sunday, November 30th, 2025 at 4:25pm ET |
| Week 14 | Denver Broncos vs. Las Vegas Raiders | Sunday, December 7th, 2025 at 4:05pm ET |
| Week 15 | Las Vegas Raiders vs. Philadelphia Eagles | Sunday, December 14th, 2025 at 1:00pm ET |
| Week 16 | Las Vegas Raiders vs. Houston Texans | Sunday, December 21st, 2025 at 4:25pm ET |
| Week 17 | New York Giants vs. Las Vegas Raiders | Sunday, December 28th, 2025 at 1:00pm ET |
| Week 18 | Kansas City Chiefs vs. Las Vegas Raiders | Sunday, January 4th, 2026 at 1:00pm ET |
