| Week 1 | Kansas City Chiefs vs. Los Angeles Chargers | Friday, September 5th, 2025 at 8:00pm ET |
| Week 2 | Los Angeles Chargers vs. Las Vegas Raiders | Monday, September 15th, 2025 at 10:00pm ET |
| Week 3 | Denver Broncos vs. Los Angeles Chargers | Sunday, September 21st, 2025 at 4:05pm ET |
| Week 4 | Los Angeles Chargers vs. New York Giants | Sunday, September 28th, 2025 at 1:00pm ET |
| Week 5 | Washington Commanders vs. Los Angeles Chargers | Sunday, October 5th, 2025 at 4:25pm ET |
| Week 6 | Los Angeles Chargers vs. Miami Dolphins | Sunday, October 12th, 2025 at 1:00pm ET |
| Week 7 | Indianapolis Colts vs. Los Angeles Chargers | Sunday, October 19th, 2025 at 4:05pm ET |
| Week 8 | Minnesota Vikings vs. Los Angeles Chargers | Thursday, October 23rd, 2025 at 8:15pm ET |
| Week 9 | Los Angeles Chargers vs. Tennessee Titans | Sunday, November 2nd, 2025 at 1:00pm ET |
| Week 10 | Pittsburgh Steelers vs. Los Angeles Chargers | Sunday, November 9th, 2025 at 8:20pm ET |
| Week 11 | Los Angeles Chargers vs. Jacksonville Jaguars | Sunday, November 16th, 2025 at 1:00pm ET |
| Week 12 | Bye Week | |
| Week 13 | Las Vegas Raiders vs. Los Angeles Chargers | Sunday, November 30th, 2025 at 4:25pm ET |
| Week 14 | Philadelphia Eagles vs. Los Angeles Chargers | Monday, December 8th, 2025 at 8:15pm ET |
| Week 15 | Los Angeles Chargers vs. Kansas City Chiefs | Sunday, December 14th, 2025 at 1:00pm ET |
| Week 16 | Los Angeles Chargers vs. Dallas Cowboys | Sunday, December 21st, 2025 at 1:00pm ET |
| Week 17 | Houston Texans vs. Los Angeles Chargers | Sunday, December 28th, 2025 at 1:00pm ET |
| Week 18 | Los Angeles Chargers vs. Denver Broncos | Sunday, January 4th, 2026 at 1:00pm ET |
