| Week 1 | Los Angeles Chargers vs. Cincinnati Bengals | Sunday, September 13th, 2020 at 4:05pm ET |
| Week 2 | Kansas City Chiefs vs. Los Angeles Chargers | Sunday, September 20th, 2020 at 4:25pm ET |
| Week 3 | Carolina Panthers vs. Los Angeles Chargers | Sunday, September 27th, 2020 at 4:05pm ET |
| Week 4 | Los Angeles Chargers vs. Tampa Bay Buccaneers | Sunday, October 4th, 2020 at 1:00pm ET |
| Week 5 | Los Angeles Chargers vs. New Orleans Saints | Monday, October 12th, 2020 at 8:15pm ET |
| Week 6 | Bye Week |
| Week 7 | Jacksonville Jaguars vs. Los Angeles Chargers | Sunday, October 25th, 2020 at 4:25pm ET |
| Week 8 | Los Angeles Chargers vs. Denver Broncos | Sunday, November 1st, 2020 at 4:05pm ET |
| Week 9 | Las Vegas Raiders vs. Los Angeles Chargers | Sunday, November 8th, 2020 at 4:05pm ET |
| Week 10 | Los Angeles Chargers vs. Miami Dolphins | Sunday, November 15th, 2020 at 4:05pm ET |
| Week 11 | New York Jets vs. Los Angeles Chargers | Sunday, November 22nd, 2020 at 4:05pm ET |
| Week 12 | Los Angeles Chargers vs. Buffalo Bills | Sunday, November 29th, 2020 at 1:00pm ET |
| Week 13 | New England Patriots vs. Los Angeles Chargers | Sunday, December 6th, 2020 at 4:25pm ET |
| Week 14 | Atlanta Falcons vs. Los Angeles Chargers | Sunday, December 13th, 2020 at 4:25pm ET |
| Week 15 | Los Angeles Chargers vs. Las Vegas Raiders | Thursday, December 17th, 2020 at 8:20pm ET |
| Week 16 | Denver Broncos vs. Los Angeles Chargers | Sunday, December 27th, 2020 at 4:05pm ET |
| Week 17 | Los Angeles Chargers vs. Kansas City Chiefs | Sunday, January 3rd, 2021 at 4:25pm ET |
