| Week 1 | Houston Texans vs. Los Angeles Rams | Sunday, September 7th, 2025 at 4:25pm ET |
| Week 2 | Los Angeles Rams vs. Tennessee Titans | Sunday, September 14th, 2025 at 1:00pm ET |
| Week 3 | Los Angeles Rams vs. Philadelphia Eagles | Sunday, September 21st, 2025 at 1:00pm ET |
| Week 4 | Indianapolis Colts vs. Los Angeles Rams | Sunday, September 28th, 2025 at 4:05pm ET |
| Week 5 | San Francisco 49ers vs. Los Angeles Rams | Thursday, October 2nd, 2025 at 8:15pm ET |
| Week 6 | Los Angeles Rams vs. Baltimore Ravens | Sunday, October 12th, 2025 at 1:00pm ET |
| Week 7 | Los Angeles Rams vs. Jacksonville Jaguars | Sunday, October 19th, 2025 at 9:30am ET |
| Week 8 | Bye Week | |
| Week 9 | New Orleans Saints vs. Los Angeles Rams | Sunday, November 2nd, 2025 at 4:05pm ET |
| Week 10 | Los Angeles Rams vs. San Francisco 49ers | Sunday, November 9th, 2025 at 4:25pm ET |
| Week 11 | Seattle Seahawks vs. Los Angeles Rams | Sunday, November 16th, 2025 at 4:05pm ET |
| Week 12 | Tampa Bay Buccaneers vs. Los Angeles Rams | Sunday, November 23rd, 2025 at 8:20pm ET |
| Week 13 | Los Angeles Rams vs. Carolina Panthers | Sunday, November 30th, 2025 at 1:00pm ET |
| Week 14 | Los Angeles Rams vs. Arizona Cardinals | Sunday, December 7th, 2025 at 4:25pm ET |
| Week 15 | Detroit Lions vs. Los Angeles Rams | Sunday, December 14th, 2025 at 4:25pm ET |
| Week 16 | Los Angeles Rams vs. Seattle Seahawks | Thursday, December 18th, 2025 at 8:15pm ET |
| Week 17 | Los Angeles Rams vs. Atlanta Falcons | Monday, December 29th, 2025 at 8:15pm ET |
| Week 18 | Arizona Cardinals vs. Los Angeles Rams | Sunday, January 4th, 2026 at 1:00pm ET |
