| Week 1 | Buffalo Bills vs. Los Angeles Rams | Thursday, September 8th, 2022 at 8:20pm ET |
| Week 2 | Atlanta Falcons vs. Los Angeles Rams | Sunday, September 18th, 2022 at 4:05pm ET |
| Week 3 | Los Angeles Rams vs. Arizona Cardinals | Sunday, September 25th, 2022 at 4:25pm ET |
| Week 4 | Los Angeles Rams vs. San Francisco 49ers | Monday, October 3rd, 2022 at 8:15pm ET |
| Week 5 | Dallas Cowboys vs. Los Angeles Rams | Sunday, October 9th, 2022 at 4:25pm ET |
| Week 6 | Carolina Panthers vs. Los Angeles Rams | Sunday, October 16th, 2022 at 4:05pm ET |
| Week 7 | Bye Week | |
| Week 8 | San Francisco 49ers vs. Los Angeles Rams | Sunday, October 30th, 2022 at 4:25pm ET |
| Week 9 | Los Angeles Rams vs. Tampa Bay Buccaneers | Sunday, November 6th, 2022 at 4:25pm ET |
| Week 10 | Arizona Cardinals vs. Los Angeles Rams | Sunday, November 13th, 2022 at 4:25pm ET |
| Week 11 | Los Angeles Rams vs. New Orleans Saints | Sunday, November 20th, 2022 at 1:00pm ET |
| Week 12 | Los Angeles Rams vs. Kansas City Chiefs | Sunday, November 27th, 2022 at 4:25pm ET |
| Week 13 | Seattle Seahawks vs. Los Angeles Rams | Sunday, December 4th, 2022 at 4:05pm ET |
| Week 14 | Las Vegas Raiders vs. Los Angeles Rams | Thursday, December 8th, 2022 at 8:15pm ET |
| Week 15 | Los Angeles Rams vs. Green Bay Packers | Monday, December 19th, 2022 at 8:15pm ET |
| Week 16 | Denver Broncos vs. Los Angeles Rams | Sunday, December 25th, 2022 at 4:30pm ET |
| Week 17 | Los Angeles Rams vs. Los Angeles Chargers | Sunday, January 1st, 2023 at 4:25pm ET |
| Week 18 | Los Angeles Rams vs. Seattle Seahawks | Sunday, January 8th, 2023 at 4:25pm ET |
