| Week 1 | San Francisco 49ers vs. Tampa Bay Buccaneers | Sunday, September 8th, 2019 at 4:25pm ET |
| Week 2 | Tampa Bay Buccaneers vs. Carolina Panthers | Thursday, September 12th, 2019 at 8:20pm ET |
| Week 3 | New York Giants vs. Tampa Bay Buccaneers | Sunday, September 22nd, 2019 at 4:05pm ET |
| Week 4 | Tampa Bay Buccaneers vs. Los Angeles Rams | Sunday, September 29th, 2019 at 4:05pm ET |
| Week 5 | Tampa Bay Buccaneers vs. New Orleans Saints | Sunday, October 6th, 2019 at 1:00pm ET |
| Week 6 | Carolina Panthers vs. Tampa Bay Buccaneers | Sunday, October 13th, 2019 at 9:30am ET |
| Week 7 | Bye Week |
| Week 8 | Tampa Bay Buccaneers vs. Tennessee Titans | Sunday, October 27th, 2019 at 1:00pm ET |
| Week 9 | Tampa Bay Buccaneers vs. Seattle Seahawks | Sunday, November 3rd, 2019 at 4:05pm ET |
| Week 10 | Arizona Cardinals vs. Tampa Bay Buccaneers | Sunday, November 10th, 2019 at 1:00pm ET |
| Week 11 | New Orleans Saints vs. Tampa Bay Buccaneers | Sunday, November 17th, 2019 at 1:00pm ET |
| Week 12 | Tampa Bay Buccaneers vs. Atlanta Falcons | Sunday, November 24th, 2019 at 1:00pm ET |
| Week 13 | Tampa Bay Buccaneers vs. Jacksonville Jaguars | Sunday, December 1st, 2019 at 1:00pm ET |
| Week 14 | Indianapolis Colts vs. Tampa Bay Buccaneers | Sunday, December 8th, 2019 at 1:00pm ET |
| Week 15 | Tampa Bay Buccaneers vs. Detroit Lions | Sunday, December 15th, 2019 at 1:00pm ET |
| Week 16 | Houston Texans vs. Tampa Bay Buccaneers | Sunday, December 22nd, 2019 at 1:00pm ET |
| Week 17 | Atlanta Falcons vs. Tampa Bay Buccaneers | Sunday, December 29th, 2019 at 1:00pm ET |
