| Week 1 | Dallas Cowboys vs. Tampa Bay Buccaneers | Thursday, September 9th, 2021 at 8:20pm ET |
| Week 2 | Atlanta Falcons vs. Tampa Bay Buccaneers | Sunday, September 19th, 2021 at 4:05pm ET |
| Week 3 | Tampa Bay Buccaneers vs. Los Angeles Rams | Sunday, September 26th, 2021 at 4:25pm ET |
| Week 4 | Tampa Bay Buccaneers vs. New England Patriots | Sunday, October 3rd, 2021 at 8:20pm ET |
| Week 5 | Miami Dolphins vs. Tampa Bay Buccaneers | Sunday, October 10th, 2021 at 1:00pm ET |
| Week 6 | Tampa Bay Buccaneers vs. Philadelphia Eagles | Thursday, October 14th, 2021 at 8:20pm ET |
| Week 7 | Chicago Bears vs. Tampa Bay Buccaneers | Sunday, October 24th, 2021 at 4:25pm ET |
| Week 8 | Tampa Bay Buccaneers vs. New Orleans Saints | Sunday, October 31st, 2021 at 4:25pm ET |
| Week 9 | Bye Week | |
| Week 10 | Tampa Bay Buccaneers vs. Washington Football Team | Sunday, November 14th, 2021 at 1:00pm ET |
| Week 11 | New York Giants vs. Tampa Bay Buccaneers | Monday, November 22nd, 2021 at 8:15pm ET |
| Week 12 | Tampa Bay Buccaneers vs. Indianapolis Colts | Sunday, November 28th, 2021 at 1:00pm ET |
| Week 13 | Tampa Bay Buccaneers vs. Atlanta Falcons | Sunday, December 5th, 2021 at 1:00pm ET |
| Week 14 | Buffalo Bills vs. Tampa Bay Buccaneers | Sunday, December 12th, 2021 at 4:25pm ET |
| Week 15 | New Orleans Saints vs. Tampa Bay Buccaneers | Sunday, December 19th, 2021 at 8:20pm ET |
| Week 16 | Tampa Bay Buccaneers vs. Carolina Panthers | Sunday, December 26th, 2021 at 1:00pm ET |
| Week 17 | Tampa Bay Buccaneers vs. New York Jets | Sunday, January 2nd, 2022 at 1:00pm ET |
| Week 18 | Carolina Panthers vs. Tampa Bay Buccaneers | Sunday, January 9th, 2022 at 1:00pm ET |
