| Week 1 | Tampa Bay Buccaneers vs. Dallas Cowboys | Sunday, September 11th, 2022 at 8:20pm ET |
| Week 2 | Tampa Bay Buccaneers vs. New Orleans Saints | Sunday, September 18th, 2022 at 1:00pm ET |
| Week 3 | Green Bay Packers vs. Tampa Bay Buccaneers | Sunday, September 25th, 2022 at 4:25pm ET |
| Week 4 | Kansas City Chiefs vs. Tampa Bay Buccaneers | Sunday, October 2nd, 2022 at 8:20pm ET |
| Week 5 | Atlanta Falcons vs. Tampa Bay Buccaneers | Sunday, October 9th, 2022 at 1:00pm ET |
| Week 6 | Tampa Bay Buccaneers vs. Pittsburgh Steelers | Sunday, October 16th, 2022 at 1:00pm ET |
| Week 7 | Tampa Bay Buccaneers vs. Carolina Panthers | Sunday, October 23rd, 2022 at 1:00pm ET |
| Week 8 | Baltimore Ravens vs. Tampa Bay Buccaneers | Thursday, October 27th, 2022 at 8:15pm ET |
| Week 9 | Los Angeles Rams vs. Tampa Bay Buccaneers | Sunday, November 6th, 2022 at 4:25pm ET |
| Week 10 | Seattle Seahawks vs. Tampa Bay Buccaneers | Sunday, November 13th, 2022 at 9:30am ET |
| Week 11 | Bye Week | |
| Week 12 | Tampa Bay Buccaneers vs. Cleveland Browns | Sunday, November 27th, 2022 at 1:00pm ET |
| Week 13 | New Orleans Saints vs. Tampa Bay Buccaneers | Monday, December 5th, 2022 at 8:15pm ET |
| Week 14 | Tampa Bay Buccaneers vs. San Francisco 49ers | Sunday, December 11th, 2022 at 4:25pm ET |
| Week 15 | Cincinnati Bengals vs. Tampa Bay Buccaneers | Sunday, December 18th, 2022 at 4:25pm ET |
| Week 16 | Tampa Bay Buccaneers vs. Arizona Cardinals | Sunday, December 25th, 2022 at 8:20pm ET |
| Week 17 | Carolina Panthers vs. Tampa Bay Buccaneers | Sunday, January 1st, 2023 at 1:00pm ET |
| Week 18 | Tampa Bay Buccaneers vs. Atlanta Falcons | Sunday, January 8th, 2023 at 1:00pm ET |
