| Week 1 | Tampa Bay Buccaneers vs. New Orleans Saints | Sunday, September 13th, 2020 at 4:25pm ET |
| Week 2 | Carolina Panthers vs. Tampa Bay Buccaneers | Sunday, September 20th, 2020 at 1:00pm ET |
| Week 3 | Tampa Bay Buccaneers vs. Denver Broncos | Sunday, September 27th, 2020 at 4:25pm ET |
| Week 4 | Los Angeles Chargers vs. Tampa Bay Buccaneers | Sunday, October 4th, 2020 at 1:00pm ET |
| Week 5 | Tampa Bay Buccaneers vs. Chicago Bears | Thursday, October 8th, 2020 at 8:20pm ET |
| Week 6 | Green Bay Packers vs. Tampa Bay Buccaneers | Sunday, October 18th, 2020 at 4:25pm ET |
| Week 7 | Tampa Bay Buccaneers vs. Las Vegas Raiders | Sunday, October 25th, 2020 at 4:05pm ET |
| Week 8 | Tampa Bay Buccaneers vs. New York Giants | Monday, November 2nd, 2020 at 8:15pm ET |
| Week 9 | New Orleans Saints vs. Tampa Bay Buccaneers | Sunday, November 8th, 2020 at 8:20pm ET |
| Week 10 | Tampa Bay Buccaneers vs. Carolina Panthers | Sunday, November 15th, 2020 at 1:00pm ET |
| Week 11 | Los Angeles Rams vs. Tampa Bay Buccaneers | Monday, November 23rd, 2020 at 8:15pm ET |
| Week 12 | Kansas City Chiefs vs. Tampa Bay Buccaneers | Sunday, November 29th, 2020 at 4:25pm ET |
| Week 13 | Bye Week |
| Week 14 | Minnesota Vikings vs. Tampa Bay Buccaneers | Sunday, December 13th, 2020 at 1:00pm ET |
| Week 15 | Tampa Bay Buccaneers vs. Atlanta Falcons | Sunday, December 20th, 2020 at 1:00pm ET |
| Week 16 | Tampa Bay Buccaneers vs. Detroit Lions | Saturday, December 26th, 2020 at 1:00pm ET |
| Week 17 | Atlanta Falcons vs. Tampa Bay Buccaneers | Sunday, January 3rd, 2021 at 1:00pm ET |
