| Week 1 | Tampa Bay Buccaneers vs. Atlanta Falcons | Sunday, September 7th, 2025 at 1:00pm ET |
| Week 2 | Tampa Bay Buccaneers vs. Houston Texans | Monday, September 15th, 2025 at 7:00pm ET |
| Week 3 | New York Jets vs. Tampa Bay Buccaneers | Sunday, September 21st, 2025 at 1:00pm ET |
| Week 4 | Philadelphia Eagles vs. Tampa Bay Buccaneers | Sunday, September 28th, 2025 at 1:00pm ET |
| Week 5 | Tampa Bay Buccaneers vs. Seattle Seahawks | Sunday, October 5th, 2025 at 4:05pm ET |
| Week 6 | San Francisco 49ers vs. Tampa Bay Buccaneers | Sunday, October 12th, 2025 at 4:25pm ET |
| Week 7 | Tampa Bay Buccaneers vs. Detroit Lions | Monday, October 20th, 2025 at 7:00pm ET |
| Week 8 | Tampa Bay Buccaneers vs. New Orleans Saints | Sunday, October 26th, 2025 at 4:05pm ET |
| Week 9 | Bye Week | |
| Week 10 | New England Patriots vs. Tampa Bay Buccaneers | Sunday, November 9th, 2025 at 1:00pm ET |
| Week 11 | Tampa Bay Buccaneers vs. Buffalo Bills | Sunday, November 16th, 2025 at 1:00pm ET |
| Week 12 | Tampa Bay Buccaneers vs. Los Angeles Rams | Sunday, November 23rd, 2025 at 8:20pm ET |
| Week 13 | Arizona Cardinals vs. Tampa Bay Buccaneers | Sunday, November 30th, 2025 at 1:00pm ET |
| Week 14 | New Orleans Saints vs. Tampa Bay Buccaneers | Sunday, December 7th, 2025 at 1:00pm ET |
| Week 15 | Atlanta Falcons vs. Tampa Bay Buccaneers | Thursday, December 11th, 2025 at 8:15pm ET |
| Week 16 | Tampa Bay Buccaneers vs. Carolina Panthers | Sunday, December 21st, 2025 at 1:00pm ET |
| Week 17 | Tampa Bay Buccaneers vs. Miami Dolphins | Sunday, December 28th, 2025 at 1:00pm ET |
| Week 18 | Carolina Panthers vs. Tampa Bay Buccaneers | Sunday, January 4th, 2026 at 1:00pm ET |
