| Week 1 | Tennessee Titans vs. Denver Broncos | Sunday, September 7th, 2025 at 4:05pm ET |
| Week 2 | Los Angeles Rams vs. Tennessee Titans | Sunday, September 14th, 2025 at 1:00pm ET |
| Week 3 | Indianapolis Colts vs. Tennessee Titans | Sunday, September 21st, 2025 at 1:00pm ET |
| Week 4 | Tennessee Titans vs. Houston Texans | Sunday, September 28th, 2025 at 1:00pm ET |
| Week 5 | Tennessee Titans vs. Arizona Cardinals | Sunday, October 5th, 2025 at 4:05pm ET |
| Week 6 | Tennessee Titans vs. Las Vegas Raiders | Sunday, October 12th, 2025 at 4:05pm ET |
| Week 7 | New England Patriots vs. Tennessee Titans | Sunday, October 19th, 2025 at 1:00pm ET |
| Week 8 | Tennessee Titans vs. Indianapolis Colts | Sunday, October 26th, 2025 at 4:25pm ET |
| Week 9 | Los Angeles Chargers vs. Tennessee Titans | Sunday, November 2nd, 2025 at 1:00pm ET |
| Week 10 | Bye Week | |
| Week 11 | Houston Texans vs. Tennessee Titans | Sunday, November 16th, 2025 at 1:00pm ET |
| Week 12 | Seattle Seahawks vs. Tennessee Titans | Sunday, November 23rd, 2025 at 1:00pm ET |
| Week 13 | Jacksonville Jaguars vs. Tennessee Titans | Sunday, November 30th, 2025 at 1:00pm ET |
| Week 14 | Tennessee Titans vs. Cleveland Browns | Sunday, December 7th, 2025 at 1:00pm ET |
| Week 15 | Tennessee Titans vs. San Francisco 49ers | Sunday, December 14th, 2025 at 4:25pm ET |
| Week 16 | Kansas City Chiefs vs. Tennessee Titans | Sunday, December 21st, 2025 at 1:00pm ET |
| Week 17 | New Orleans Saints vs. Tennessee Titans | Sunday, December 28th, 2025 at 1:00pm ET |
| Week 18 | Tennessee Titans vs. Jacksonville Jaguars | Sunday, January 4th, 2026 at 1:00pm ET |
