| Week 1 | Carolina Panthers vs. Jacksonville Jaguars | Sunday, September 7th, 2025 at 1:00pm ET |
| Week 2 | Jacksonville Jaguars vs. Cincinnati Bengals | Sunday, September 14th, 2025 at 1:00pm ET |
| Week 3 | Houston Texans vs. Jacksonville Jaguars | Sunday, September 21st, 2025 at 1:00pm ET |
| Week 4 | Jacksonville Jaguars vs. San Francisco 49ers | Sunday, September 28th, 2025 at 4:05pm ET |
| Week 5 | Kansas City Chiefs vs. Jacksonville Jaguars | Monday, October 6th, 2025 at 8:15pm ET |
| Week 6 | Seattle Seahawks vs. Jacksonville Jaguars | Sunday, October 12th, 2025 at 1:00pm ET |
| Week 7 | Los Angeles Rams vs. Jacksonville Jaguars | Sunday, October 19th, 2025 at 9:30am ET |
| Week 8 | Bye Week | |
| Week 9 | Jacksonville Jaguars vs. Las Vegas Raiders | Sunday, November 2nd, 2025 at 4:05pm ET |
| Week 10 | Jacksonville Jaguars vs. Houston Texans | Sunday, November 9th, 2025 at 1:00pm ET |
| Week 11 | Los Angeles Chargers vs. Jacksonville Jaguars | Sunday, November 16th, 2025 at 1:00pm ET |
| Week 12 | Jacksonville Jaguars vs. Arizona Cardinals | Sunday, November 23rd, 2025 at 4:05pm ET |
| Week 13 | Jacksonville Jaguars vs. Tennessee Titans | Sunday, November 30th, 2025 at 1:00pm ET |
| Week 14 | Indianapolis Colts vs. Jacksonville Jaguars | Sunday, December 7th, 2025 at 1:00pm ET |
| Week 15 | New York Jets vs. Jacksonville Jaguars | Sunday, December 14th, 2025 at 1:00pm ET |
| Week 16 | Jacksonville Jaguars vs. Denver Broncos | Sunday, December 21st, 2025 at 4:05pm ET |
| Week 17 | Jacksonville Jaguars vs. Indianapolis Colts | Sunday, December 28th, 2025 at 1:00pm ET |
| Week 18 | Tennessee Titans vs. Jacksonville Jaguars | Sunday, January 4th, 2026 at 1:00pm ET |
