| Week 1 | Philadelphia Eagles vs. New England Patriots | Sunday, September 10th, 2023 at 4:25pm ET |
| Week 2 | Miami Dolphins vs. New England Patriots | Sunday, September 17th, 2023 at 8:20pm ET |
| Week 3 | New England Patriots vs. New York Jets | Sunday, September 24th, 2023 at 1:00pm ET |
| Week 4 | New England Patriots vs. Dallas Cowboys | Sunday, October 1st, 2023 at 4:25pm ET |
| Week 5 | New Orleans Saints vs. New England Patriots | Sunday, October 8th, 2023 at 1:00pm ET |
| Week 6 | New England Patriots vs. Las Vegas Raiders | Sunday, October 15th, 2023 at 4:05pm ET |
| Week 7 | Buffalo Bills vs. New England Patriots | Sunday, October 22nd, 2023 at 1:00pm ET |
| Week 8 | New England Patriots vs. Miami Dolphins | Sunday, October 29th, 2023 at 1:00pm ET |
| Week 9 | Washington Commanders vs. New England Patriots | Sunday, November 5th, 2023 at 1:00pm ET |
| Week 10 | Indianapolis Colts vs. New England Patriots | Sunday, November 12th, 2023 at 9:30am ET |
| Week 11 | Bye Week | |
| Week 12 | New England Patriots vs. New York Giants | Sunday, November 26th, 2023 at 1:00pm ET |
| Week 13 | Los Angeles Chargers vs. New England Patriots | Sunday, December 3rd, 2023 at 1:00pm ET |
| Week 14 | New England Patriots vs. Pittsburgh Steelers | Thursday, December 7th, 2023 at 8:15pm ET |
| Week 15 | Kansas City Chiefs vs. New England Patriots | Sunday, December 17th, 2023 at 1:00pm ET |
| Week 16 | New England Patriots vs. Denver Broncos | Sunday, December 24th, 2023 at 8:15pm ET |
| Week 17 | New England Patriots vs. Buffalo Bills | Sunday, December 31st, 2023 at 1:00pm ET |
| Week 18 | New York Jets vs. New England Patriots | Sunday, January 7th, 2024 at 1:00pm ET |
