| Week 1 | Las Vegas Raiders vs. New England Patriots | Sunday, September 7th, 2025 at 1:00pm ET |
| Week 2 | New England Patriots vs. Miami Dolphins | Sunday, September 14th, 2025 at 1:00pm ET |
| Week 3 | Pittsburgh Steelers vs. New England Patriots | Sunday, September 21st, 2025 at 1:00pm ET |
| Week 4 | Carolina Panthers vs. New England Patriots | Sunday, September 28th, 2025 at 1:00pm ET |
| Week 5 | New England Patriots vs. Buffalo Bills | Sunday, October 5th, 2025 at 8:20pm ET |
| Week 6 | New England Patriots vs. New Orleans Saints | Sunday, October 12th, 2025 at 1:00pm ET |
| Week 7 | New England Patriots vs. Tennessee Titans | Sunday, October 19th, 2025 at 1:00pm ET |
| Week 8 | Cleveland Browns vs. New England Patriots | Sunday, October 26th, 2025 at 1:00pm ET |
| Week 9 | Atlanta Falcons vs. New England Patriots | Sunday, November 2nd, 2025 at 1:00pm ET |
| Week 10 | New England Patriots vs. Tampa Bay Buccaneers | Sunday, November 9th, 2025 at 1:00pm ET |
| Week 11 | New York Jets vs. New England Patriots | Thursday, November 13th, 2025 at 8:15pm ET |
| Week 12 | New England Patriots vs. Cincinnati Bengals | Sunday, November 23rd, 2025 at 1:00pm ET |
| Week 13 | New York Giants vs. New England Patriots | Monday, December 1st, 2025 at 8:15pm ET |
| Week 14 | Bye Week | |
| Week 15 | Buffalo Bills vs. New England Patriots | Sunday, December 14th, 2025 at 1:00pm ET |
| Week 16 | New England Patriots vs. Baltimore Ravens | Sunday, December 21st, 2025 at 1:00pm ET |
| Week 17 | New England Patriots vs. New York Jets | Sunday, December 28th, 2025 at 1:00pm ET |
| Week 18 | Miami Dolphins vs. New England Patriots | Sunday, January 4th, 2026 at 1:00pm ET |
