| Week 1 | San Francisco 49ers vs. Pittsburgh Steelers | Sunday, September 10th, 2023 at 1:00pm ET |
| Week 2 | Cleveland Browns vs. Pittsburgh Steelers | Monday, September 18th, 2023 at 8:15pm ET |
| Week 3 | Pittsburgh Steelers vs. Las Vegas Raiders | Sunday, September 24th, 2023 at 8:20pm ET |
| Week 4 | Pittsburgh Steelers vs. Houston Texans | Sunday, October 1st, 2023 at 1:00pm ET |
| Week 5 | Baltimore Ravens vs. Pittsburgh Steelers | Sunday, October 8th, 2023 at 1:00pm ET |
| Week 6 | Bye Week | |
| Week 7 | Pittsburgh Steelers vs. Los Angeles Rams | Sunday, October 22nd, 2023 at 4:05pm ET |
| Week 8 | Jacksonville Jaguars vs. Pittsburgh Steelers | Sunday, October 29th, 2023 at 1:00pm ET |
| Week 9 | Tennessee Titans vs. Pittsburgh Steelers | Thursday, November 2nd, 2023 at 8:15pm ET |
| Week 10 | Green Bay Packers vs. Pittsburgh Steelers | Sunday, November 12th, 2023 at 1:00pm ET |
| Week 11 | Pittsburgh Steelers vs. Cleveland Browns | Sunday, November 19th, 2023 at 1:00pm ET |
| Week 12 | Pittsburgh Steelers vs. Cincinnati Bengals | Sunday, November 26th, 2023 at 1:00pm ET |
| Week 13 | Arizona Cardinals vs. Pittsburgh Steelers | Sunday, December 3rd, 2023 at 1:00pm ET |
| Week 14 | New England Patriots vs. Pittsburgh Steelers | Thursday, December 7th, 2023 at 8:15pm ET |
| Week 15 | Pittsburgh Steelers vs. Indianapolis Colts | Saturday, December 16th, 2023 at 4:30pm ET |
| Week 16 | Cincinnati Bengals vs. Pittsburgh Steelers | Saturday, December 23rd, 2023 at 4:30pm ET |
| Week 17 | Pittsburgh Steelers vs. Seattle Seahawks | Sunday, December 31st, 2023 at 4:05pm ET |
| Week 18 | Pittsburgh Steelers vs. Baltimore Ravens | Saturday, January 6th, 2024 at 4:30pm ET |
