| Week 1 | Atlanta Falcons vs. Pittsburgh Steelers | Sunday, September 13th, 2026 at 1:00pm ET |
| Week 2 | Pittsburgh Steelers vs. New England Patriots | Sunday, September 20th, 2026 at 1:00pm ET |
| Week 3 | Cincinnati Bengals vs. Pittsburgh Steelers | Sunday, September 27th, 2026 at 1:00pm ET |
| Week 4 | Pittsburgh Steelers vs. Cleveland Browns | Thursday, October 1st, 2026 at 8:15pm ET |
| Week 5 | Indianapolis Colts vs. Pittsburgh Steelers | Sunday, October 11th, 2026 at 1:00pm ET |
| Week 6 | Pittsburgh Steelers vs. Tampa Bay Buccaneers | Sunday, October 18th, 2026 at 1:00pm ET |
| Week 7 | Pittsburgh Steelers vs. New Orleans Saints | Sunday, October 25th, 2026 at 9:30am ET |
| Week 8 | Cleveland Browns vs. Pittsburgh Steelers | Sunday, November 1st, 2026 at 1:00pm ET |
| Week 9 | Bye Week | |
| Week 10 | Pittsburgh Steelers vs. Cincinnati Bengals | Sunday, November 15th, 2026 at 8:20pm ET |
| Week 11 | Pittsburgh Steelers vs. Philadelphia Eagles | Sunday, November 22nd, 2026 at 4:25pm ET |
| Week 12 | Denver Broncos vs. Pittsburgh Steelers | Friday, November 27th, 2026 at 3:00pm ET |
| Week 13 | Houston Texans vs. Pittsburgh Steelers | Sunday, December 6th, 2026 at 8:20pm ET |
| Week 14 | Pittsburgh Steelers vs. Jacksonville Jaguars | Monday, December 14th, 2026 at 8:15pm ET |
| Week 15 | Baltimore Ravens vs. Pittsburgh Steelers | Sunday, December 20th, 2026 at 1:00pm ET |
| Week 16 | Carolina Panthers vs. Pittsburgh Steelers | Sunday, December 27th, 2026 at 1:00pm ET |
| Week 17 | Pittsburgh Steelers vs. Tennessee Titans | Sunday, January 3rd, 2027 at 1:00pm ET |
| Week 18 | Pittsburgh Steelers vs. Baltimore Ravens | Sunday, January 10th, 2027 at 1:00pm ET |
