| Week 1 | Pittsburgh Steelers vs. New York Jets | Sunday, September 7th, 2025 at 1:00pm ET |
| Week 2 | Seattle Seahawks vs. Pittsburgh Steelers | Sunday, September 14th, 2025 at 1:00pm ET |
| Week 3 | Pittsburgh Steelers vs. New England Patriots | Sunday, September 21st, 2025 at 1:00pm ET |
| Week 4 | Minnesota Vikings vs. Pittsburgh Steelers | Sunday, September 28th, 2025 at 9:30am ET |
| Week 5 | Bye Week | |
| Week 6 | Cleveland Browns vs. Pittsburgh Steelers | Sunday, October 12th, 2025 at 1:00pm ET |
| Week 7 | Pittsburgh Steelers vs. Cincinnati Bengals | Thursday, October 16th, 2025 at 8:15pm ET |
| Week 8 | Green Bay Packers vs. Pittsburgh Steelers | Sunday, October 26th, 2025 at 8:20pm ET |
| Week 9 | Indianapolis Colts vs. Pittsburgh Steelers | Sunday, November 2nd, 2025 at 1:00pm ET |
| Week 10 | Pittsburgh Steelers vs. Los Angeles Chargers | Sunday, November 9th, 2025 at 8:20pm ET |
| Week 11 | Cincinnati Bengals vs. Pittsburgh Steelers | Sunday, November 16th, 2025 at 1:00pm ET |
| Week 12 | Pittsburgh Steelers vs. Chicago Bears | Sunday, November 23rd, 2025 at 1:00pm ET |
| Week 13 | Buffalo Bills vs. Pittsburgh Steelers | Sunday, November 30th, 2025 at 4:25pm ET |
| Week 14 | Pittsburgh Steelers vs. Baltimore Ravens | Sunday, December 7th, 2025 at 1:00pm ET |
| Week 15 | Miami Dolphins vs. Pittsburgh Steelers | Monday, December 15th, 2025 at 8:15pm ET |
| Week 16 | Pittsburgh Steelers vs. Detroit Lions | Sunday, December 21st, 2025 at 4:25pm ET |
| Week 17 | Pittsburgh Steelers vs. Cleveland Browns | Sunday, December 28th, 2025 at 1:00pm ET |
| Week 18 | Baltimore Ravens vs. Pittsburgh Steelers | Sunday, January 4th, 2026 at 1:00pm ET |
