| Week 1 | Carolina Panthers vs. Jacksonville Jaguars | Sunday, September 7th, 2025 at 1:00pm ET |
| Week 2 | Carolina Panthers vs. Arizona Cardinals | Sunday, September 14th, 2025 at 4:05pm ET |
| Week 3 | Atlanta Falcons vs. Carolina Panthers | Sunday, September 21st, 2025 at 1:00pm ET |
| Week 4 | Carolina Panthers vs. New England Patriots | Sunday, September 28th, 2025 at 1:00pm ET |
| Week 5 | Miami Dolphins vs. Carolina Panthers | Sunday, October 5th, 2025 at 1:00pm ET |
| Week 6 | Dallas Cowboys vs. Carolina Panthers | Sunday, October 12th, 2025 at 1:00pm ET |
| Week 7 | Carolina Panthers vs. New York Jets | Sunday, October 19th, 2025 at 1:00pm ET |
| Week 8 | Buffalo Bills vs. Carolina Panthers | Sunday, October 26th, 2025 at 1:00pm ET |
| Week 9 | Carolina Panthers vs. Green Bay Packers | Sunday, November 2nd, 2025 at 1:00pm ET |
| Week 10 | New Orleans Saints vs. Carolina Panthers | Sunday, November 9th, 2025 at 1:00pm ET |
| Week 11 | Carolina Panthers vs. Atlanta Falcons | Sunday, November 16th, 2025 at 1:00pm ET |
| Week 12 | Carolina Panthers vs. San Francisco 49ers | Monday, November 24th, 2025 at 8:15pm ET |
| Week 13 | Los Angeles Rams vs. Carolina Panthers | Sunday, November 30th, 2025 at 1:00pm ET |
| Week 14 | Bye Week | |
| Week 15 | Carolina Panthers vs. New Orleans Saints | Sunday, December 14th, 2025 at 4:25pm ET |
| Week 16 | Tampa Bay Buccaneers vs. Carolina Panthers | Sunday, December 21st, 2025 at 1:00pm ET |
| Week 17 | Seattle Seahawks vs. Carolina Panthers | Sunday, December 28th, 2025 at 1:00pm ET |
| Week 18 | Carolina Panthers vs. Tampa Bay Buccaneers | Sunday, January 4th, 2026 at 1:00pm ET |
