| Week 1 | New Orleans Saints vs. Detroit Lions | Sunday, September 13th, 2026 at 1:00pm ET |
| Week 2 | Detroit Lions vs. Buffalo Bills | Thursday, September 17th, 2026 at 8:15pm ET |
| Week 3 | New York Jets vs. Detroit Lions | Sunday, September 27th, 2026 at 1:00pm ET |
| Week 4 | Detroit Lions vs. Carolina Panthers | Sunday, October 4th, 2026 at 8:20pm ET |
| Week 5 | Detroit Lions vs. Arizona Cardinals | Sunday, October 11th, 2026 at 4:25pm ET |
| Week 6 | Bye Week | |
| Week 7 | Green Bay Packers vs. Detroit Lions | Sunday, October 25th, 2026 at 4:25pm ET |
| Week 8 | Minnesota Vikings vs. Detroit Lions | Sunday, November 1st, 2026 at 1:00pm ET |
| Week 9 | Detroit Lions vs. Miami Dolphins | Sunday, November 8th, 2026 at 1:00pm ET |
| Week 10 | New England Patriots vs. Detroit Lions | Sunday, November 15th, 2026 at 9:30am ET |
| Week 11 | Tampa Bay Buccaneers vs. Detroit Lions | Sunday, November 22nd, 2026 at 1:00pm ET |
| Week 12 | Chicago Bears vs. Detroit Lions | Thursday, November 26th, 2026 at 1:00pm ET |
| Week 13 | Detroit Lions vs. Atlanta Falcons | Sunday, December 6th, 2026 at 1:00pm ET |
| Week 14 | Tennessee Titans vs. Detroit Lions | Sunday, December 13th, 2026 at 1:00pm ET |
| Week 15 | Detroit Lions vs. Minnesota Vikings | Sunday, December 20th, 2026 at 8:20pm ET |
| Week 16 | New York Giants vs. Detroit Lions | Monday, December 28th, 2026 at 8:15pm ET |
| Week 17 | Detroit Lions vs. Chicago Bears | Sunday, January 3rd, 2027 at 4:25pm ET |
| Week 18 | Detroit Lions vs. Green Bay Packers | Sunday, January 10th, 2027 at 1:00pm ET |
