| Week 1 | Detroit Lions vs. Arizona Cardinals | Sunday, September 8th, 2019 at 4:25pm ET |
| Week 2 | Los Angeles Chargers vs. Detroit Lions | Sunday, September 15th, 2019 at 1:00pm ET |
| Week 3 | Detroit Lions vs. Philadelphia Eagles | Sunday, September 22nd, 2019 at 1:00pm ET |
| Week 4 | Kansas City Chiefs vs. Detroit Lions | Sunday, September 29th, 2019 at 1:00pm ET |
| Week 5 | Bye Week |
| Week 6 | Detroit Lions vs. Green Bay Packers | Monday, October 14th, 2019 at 8:15pm ET |
| Week 7 | Minnesota Vikings vs. Detroit Lions | Sunday, October 20th, 2019 at 1:00pm ET |
| Week 8 | New York Giants vs. Detroit Lions | Sunday, October 27th, 2019 at 1:00pm ET |
| Week 9 | Detroit Lions vs. Oakland Raiders | Sunday, November 3rd, 2019 at 4:05pm ET |
| Week 10 | Detroit Lions vs. Chicago Bears | Sunday, November 10th, 2019 at 1:00pm ET |
| Week 11 | Dallas Cowboys vs. Detroit Lions | Sunday, November 17th, 2019 at 1:00pm ET |
| Week 12 | Detroit Lions vs. Washington | Sunday, November 24th, 2019 at 1:00pm ET |
| Week 13 | Chicago Bears vs. Detroit Lions | Thursday, November 28th, 2019 at 12:30pm ET |
| Week 14 | Detroit Lions vs. Minnesota Vikings | Sunday, December 8th, 2019 at 1:00pm ET |
| Week 15 | Tampa Bay Buccaneers vs. Detroit Lions | Sunday, December 15th, 2019 at 1:00pm ET |
| Week 16 | Detroit Lions vs. Denver Broncos | Sunday, December 22nd, 2019 at 4:05pm ET |
| Week 17 | Green Bay Packers vs. Detroit Lions | Sunday, December 29th, 2019 at 1:00pm ET |
