| Week 1 | Kansas City Chiefs vs. Jacksonville Jaguars | Sunday, September 8th, 2019 at 1:00pm ET |
| Week 2 | Kansas City Chiefs vs. Oakland Raiders | Sunday, September 15th, 2019 at 4:05pm ET |
| Week 3 | Baltimore Ravens vs. Kansas City Chiefs | Sunday, September 22nd, 2019 at 1:00pm ET |
| Week 4 | Kansas City Chiefs vs. Detroit Lions | Sunday, September 29th, 2019 at 1:00pm ET |
| Week 5 | Indianapolis Colts vs. Kansas City Chiefs | Sunday, October 6th, 2019 at 8:20pm ET |
| Week 6 | Houston Texans vs. Kansas City Chiefs | Sunday, October 13th, 2019 at 1:00pm ET |
| Week 7 | Kansas City Chiefs vs. Denver Broncos | Thursday, October 17th, 2019 at 8:20pm ET |
| Week 8 | Green Bay Packers vs. Kansas City Chiefs | Sunday, October 27th, 2019 at 8:20pm ET |
| Week 9 | Minnesota Vikings vs. Kansas City Chiefs | Sunday, November 3rd, 2019 at 1:00pm ET |
| Week 10 | Kansas City Chiefs vs. Tennessee Titans | Sunday, November 10th, 2019 at 1:00pm ET |
| Week 11 | Kansas City Chiefs vs. Los Angeles Chargers | Monday, November 18th, 2019 at 8:15pm ET |
| Week 12 | Bye Week |
| Week 13 | Oakland Raiders vs. Kansas City Chiefs | Sunday, December 1st, 2019 at 1:00pm ET |
| Week 14 | Kansas City Chiefs vs. New England Patriots | Sunday, December 8th, 2019 at 4:25pm ET |
| Week 15 | Denver Broncos vs. Kansas City Chiefs | Sunday, December 15th, 2019 at 1:00pm ET |
| Week 16 | Kansas City Chiefs vs. Chicago Bears | Sunday, December 22nd, 2019 at 8:20pm ET |
| Week 17 | Los Angeles Chargers vs. Kansas City Chiefs | Sunday, December 29th, 2019 at 1:00pm ET |
