| Week 1 | Kansas City Chiefs vs. Arizona Cardinals | Sunday, September 11th, 2022 at 4:25pm ET |
| Week 2 | Los Angeles Chargers vs. Kansas City Chiefs | Thursday, September 15th, 2022 at 8:15pm ET |
| Week 3 | Kansas City Chiefs vs. Indianapolis Colts | Sunday, September 25th, 2022 at 1:00pm ET |
| Week 4 | Kansas City Chiefs vs. Tampa Bay Buccaneers | Sunday, October 2nd, 2022 at 8:20pm ET |
| Week 5 | Las Vegas Raiders vs. Kansas City Chiefs | Monday, October 10th, 2022 at 8:15pm ET |
| Week 6 | Buffalo Bills vs. Kansas City Chiefs | Sunday, October 16th, 2022 at 4:25pm ET |
| Week 7 | Kansas City Chiefs vs. San Francisco 49ers | Sunday, October 23rd, 2022 at 4:25pm ET |
| Week 8 | Bye Week | |
| Week 9 | Tennessee Titans vs. Kansas City Chiefs | Sunday, November 6th, 2022 at 8:20pm ET |
| Week 10 | Jacksonville Jaguars vs. Kansas City Chiefs | Sunday, November 13th, 2022 at 1:00pm ET |
| Week 11 | Kansas City Chiefs vs. Los Angeles Chargers | Sunday, November 20th, 2022 at 4:25pm ET |
| Week 12 | Los Angeles Rams vs. Kansas City Chiefs | Sunday, November 27th, 2022 at 4:25pm ET |
| Week 13 | Kansas City Chiefs vs. Cincinnati Bengals | Sunday, December 4th, 2022 at 4:25pm ET |
| Week 14 | Kansas City Chiefs vs. Denver Broncos | Sunday, December 11th, 2022 at 8:20pm ET |
| Week 15 | Kansas City Chiefs vs. Houston Texans | Sunday, December 18th, 2022 at 1:00pm ET |
| Week 16 | Seattle Seahawks vs. Kansas City Chiefs | Saturday, December 24th, 2022 at 1:00pm ET |
| Week 17 | Denver Broncos vs. Kansas City Chiefs | Sunday, January 1st, 2023 at 1:00pm ET |
| Week 18 | Kansas City Chiefs vs. Las Vegas Raiders | Sunday, January 8th, 2023 at 1:00pm ET |
