| Week 1 | Kansas City Chiefs vs. Los Angeles Chargers | Friday, September 5th, 2025 at 8:00pm ET |
| Week 2 | Philadelphia Eagles vs. Kansas City Chiefs | Sunday, September 14th, 2025 at 4:25pm ET |
| Week 3 | Kansas City Chiefs vs. New York Giants | Sunday, September 21st, 2025 at 8:20pm ET |
| Week 4 | Baltimore Ravens vs. Kansas City Chiefs | Sunday, September 28th, 2025 at 4:25pm ET |
| Week 5 | Kansas City Chiefs vs. Jacksonville Jaguars | Monday, October 6th, 2025 at 8:15pm ET |
| Week 6 | Detroit Lions vs. Kansas City Chiefs | Sunday, October 12th, 2025 at 8:20pm ET |
| Week 7 | Las Vegas Raiders vs. Kansas City Chiefs | Sunday, October 19th, 2025 at 1:00pm ET |
| Week 8 | Washington Commanders vs. Kansas City Chiefs | Monday, October 27th, 2025 at 8:15pm ET |
| Week 9 | Kansas City Chiefs vs. Buffalo Bills | Sunday, November 2nd, 2025 at 4:25pm ET |
| Week 10 | Bye Week | |
| Week 11 | Kansas City Chiefs vs. Denver Broncos | Sunday, November 16th, 2025 at 4:25pm ET |
| Week 12 | Indianapolis Colts vs. Kansas City Chiefs | Sunday, November 23rd, 2025 at 1:00pm ET |
| Week 13 | Kansas City Chiefs vs. Dallas Cowboys | Thursday, November 27th, 2025 at 4:30pm ET |
| Week 14 | Houston Texans vs. Kansas City Chiefs | Sunday, December 7th, 2025 at 8:20pm ET |
| Week 15 | Los Angeles Chargers vs. Kansas City Chiefs | Sunday, December 14th, 2025 at 1:00pm ET |
| Week 16 | Kansas City Chiefs vs. Tennessee Titans | Sunday, December 21st, 2025 at 1:00pm ET |
| Week 17 | Denver Broncos vs. Kansas City Chiefs | Thursday, December 25th, 2025 at 8:15pm ET |
| Week 18 | Kansas City Chiefs vs. Las Vegas Raiders | Sunday, January 4th, 2026 at 1:00pm ET |
