| Week 1 | Detroit Lions vs. Kansas City Chiefs | Thursday, September 7th, 2023 at 8:20pm ET |
| Week 2 | Kansas City Chiefs vs. Jacksonville Jaguars | Sunday, September 17th, 2023 at 1:00pm ET |
| Week 3 | Chicago Bears vs. Kansas City Chiefs | Sunday, September 24th, 2023 at 4:25pm ET |
| Week 4 | Kansas City Chiefs vs. New York Jets | Sunday, October 1st, 2023 at 8:20pm ET |
| Week 5 | Kansas City Chiefs vs. Minnesota Vikings | Sunday, October 8th, 2023 at 4:25pm ET |
| Week 6 | Denver Broncos vs. Kansas City Chiefs | Thursday, October 12th, 2023 at 8:15pm ET |
| Week 7 | Los Angeles Chargers vs. Kansas City Chiefs | Sunday, October 22nd, 2023 at 4:25pm ET |
| Week 8 | Kansas City Chiefs vs. Denver Broncos | Sunday, October 29th, 2023 at 4:25pm ET |
| Week 9 | Miami Dolphins vs. Kansas City Chiefs | Sunday, November 5th, 2023 at 9:30am ET |
| Week 10 | Bye Week | |
| Week 11 | Philadelphia Eagles vs. Kansas City Chiefs | Monday, November 20th, 2023 at 8:15pm ET |
| Week 12 | Kansas City Chiefs vs. Las Vegas Raiders | Sunday, November 26th, 2023 at 4:25pm ET |
| Week 13 | Kansas City Chiefs vs. Green Bay Packers | Sunday, December 3rd, 2023 at 8:20pm ET |
| Week 14 | Buffalo Bills vs. Kansas City Chiefs | Sunday, December 10th, 2023 at 4:25pm ET |
| Week 15 | Kansas City Chiefs vs. New England Patriots | Sunday, December 17th, 2023 at 1:00pm ET |
| Week 16 | Las Vegas Raiders vs. Kansas City Chiefs | Monday, December 25th, 2023 at 1:00pm ET |
| Week 17 | Cincinnati Bengals vs. Kansas City Chiefs | Sunday, December 31st, 2023 at 4:25pm ET |
| Week 18 | Kansas City Chiefs vs. Los Angeles Chargers | Sunday, January 7th, 2024 at 1:00pm ET |
