| Week 1 | Minnesota Vikings vs. Chicago Bears | Monday, September 8th, 2025 at 8:15pm ET |
| Week 2 | Atlanta Falcons vs. Minnesota Vikings | Sunday, September 14th, 2025 at 8:20pm ET |
| Week 3 | Cincinnati Bengals vs. Minnesota Vikings | Sunday, September 21st, 2025 at 1:00pm ET |
| Week 4 | Minnesota Vikings vs. Pittsburgh Steelers | Sunday, September 28th, 2025 at 9:30am ET |
| Week 5 | Minnesota Vikings vs. Cleveland Browns | Sunday, October 5th, 2025 at 9:30am ET |
| Week 6 | Bye Week | |
| Week 7 | Philadelphia Eagles vs. Minnesota Vikings | Sunday, October 19th, 2025 at 1:00pm ET |
| Week 8 | Minnesota Vikings vs. Los Angeles Chargers | Thursday, October 23rd, 2025 at 8:15pm ET |
| Week 9 | Minnesota Vikings vs. Detroit Lions | Sunday, November 2nd, 2025 at 1:00pm ET |
| Week 10 | Baltimore Ravens vs. Minnesota Vikings | Sunday, November 9th, 2025 at 1:00pm ET |
| Week 11 | Chicago Bears vs. Minnesota Vikings | Sunday, November 16th, 2025 at 1:00pm ET |
| Week 12 | Minnesota Vikings vs. Green Bay Packers | Sunday, November 23rd, 2025 at 1:00pm ET |
| Week 13 | Minnesota Vikings vs. Seattle Seahawks | Sunday, November 30th, 2025 at 4:05pm ET |
| Week 14 | Washington Commanders vs. Minnesota Vikings | Sunday, December 7th, 2025 at 1:00pm ET |
| Week 15 | Minnesota Vikings vs. Dallas Cowboys | Sunday, December 14th, 2025 at 8:20pm ET |
| Week 16 | Minnesota Vikings vs. New York Giants | Sunday, December 21st, 2025 at 1:00pm ET |
| Week 17 | Detroit Lions vs. Minnesota Vikings | Thursday, December 25th, 2025 at 4:30pm ET |
| Week 18 | Green Bay Packers vs. Minnesota Vikings | Sunday, January 4th, 2026 at 1:00pm ET |
