| Week 1 | Arizona Cardinals vs. New Orleans Saints | Sunday, September 7th, 2025 at 1:00pm ET |
| Week 2 | San Francisco 49ers vs. New Orleans Saints | Sunday, September 14th, 2025 at 1:00pm ET |
| Week 3 | New Orleans Saints vs. Seattle Seahawks | Sunday, September 21st, 2025 at 4:05pm ET |
| Week 4 | New Orleans Saints vs. Buffalo Bills | Sunday, September 28th, 2025 at 1:00pm ET |
| Week 5 | New York Giants vs. New Orleans Saints | Sunday, October 5th, 2025 at 1:00pm ET |
| Week 6 | New England Patriots vs. New Orleans Saints | Sunday, October 12th, 2025 at 1:00pm ET |
| Week 7 | New Orleans Saints vs. Chicago Bears | Sunday, October 19th, 2025 at 1:00pm ET |
| Week 8 | Tampa Bay Buccaneers vs. New Orleans Saints | Sunday, October 26th, 2025 at 4:05pm ET |
| Week 9 | New Orleans Saints vs. Los Angeles Rams | Sunday, November 2nd, 2025 at 4:05pm ET |
| Week 10 | New Orleans Saints vs. Carolina Panthers | Sunday, November 9th, 2025 at 1:00pm ET |
| Week 11 | Bye Week | |
| Week 12 | Atlanta Falcons vs. New Orleans Saints | Sunday, November 23rd, 2025 at 4:25pm ET |
| Week 13 | New Orleans Saints vs. Miami Dolphins | Sunday, November 30th, 2025 at 1:00pm ET |
| Week 14 | New Orleans Saints vs. Tampa Bay Buccaneers | Sunday, December 7th, 2025 at 1:00pm ET |
| Week 15 | Carolina Panthers vs. New Orleans Saints | Sunday, December 14th, 2025 at 4:25pm ET |
| Week 16 | New York Jets vs. New Orleans Saints | Sunday, December 21st, 2025 at 1:00pm ET |
| Week 17 | New Orleans Saints vs. Tennessee Titans | Sunday, December 28th, 2025 at 1:00pm ET |
| Week 18 | New Orleans Saints vs. Atlanta Falcons | Sunday, January 4th, 2026 at 1:00pm ET |
