| Week 1 | New York Giants vs. Washington Commanders | Sunday, September 7th, 2025 at 1:00pm ET |
| Week 2 | New York Giants vs. Dallas Cowboys | Sunday, September 14th, 2025 at 1:00pm ET |
| Week 3 | Kansas City Chiefs vs. New York Giants | Sunday, September 21st, 2025 at 8:20pm ET |
| Week 4 | Los Angeles Chargers vs. New York Giants | Sunday, September 28th, 2025 at 1:00pm ET |
| Week 5 | New York Giants vs. New Orleans Saints | Sunday, October 5th, 2025 at 1:00pm ET |
| Week 6 | Philadelphia Eagles vs. New York Giants | Thursday, October 9th, 2025 at 8:15pm ET |
| Week 7 | New York Giants vs. Denver Broncos | Sunday, October 19th, 2025 at 4:05pm ET |
| Week 8 | New York Giants vs. Philadelphia Eagles | Sunday, October 26th, 2025 at 1:00pm ET |
| Week 9 | San Francisco 49ers vs. New York Giants | Sunday, November 2nd, 2025 at 1:00pm ET |
| Week 10 | New York Giants vs. Chicago Bears | Sunday, November 9th, 2025 at 1:00pm ET |
| Week 11 | Green Bay Packers vs. New York Giants | Sunday, November 16th, 2025 at 1:00pm ET |
| Week 12 | New York Giants vs. Detroit Lions | Sunday, November 23rd, 2025 at 1:00pm ET |
| Week 13 | New York Giants vs. New England Patriots | Monday, December 1st, 2025 at 8:15pm ET |
| Week 14 | Bye Week | |
| Week 15 | Washington Commanders vs. New York Giants | Sunday, December 14th, 2025 at 1:00pm ET |
| Week 16 | Minnesota Vikings vs. New York Giants | Sunday, December 21st, 2025 at 1:00pm ET |
| Week 17 | New York Giants vs. Las Vegas Raiders | Sunday, December 28th, 2025 at 1:00pm ET |
| Week 18 | Dallas Cowboys vs. New York Giants | Sunday, January 4th, 2026 at 1:00pm ET |
