| Week 1 | Dallas Cowboys vs. Philadelphia Eagles | Thursday, September 4th, 2025 at 8:20pm ET |
| Week 2 | Philadelphia Eagles vs. Kansas City Chiefs | Sunday, September 14th, 2025 at 4:25pm ET |
| Week 3 | Los Angeles Rams vs. Philadelphia Eagles | Sunday, September 21st, 2025 at 1:00pm ET |
| Week 4 | Philadelphia Eagles vs. Tampa Bay Buccaneers | Sunday, September 28th, 2025 at 1:00pm ET |
| Week 5 | Denver Broncos vs. Philadelphia Eagles | Sunday, October 5th, 2025 at 1:00pm ET |
| Week 6 | Philadelphia Eagles vs. New York Giants | Thursday, October 9th, 2025 at 8:15pm ET |
| Week 7 | Philadelphia Eagles vs. Minnesota Vikings | Sunday, October 19th, 2025 at 1:00pm ET |
| Week 8 | New York Giants vs. Philadelphia Eagles | Sunday, October 26th, 2025 at 1:00pm ET |
| Week 9 | Bye Week | |
| Week 10 | Philadelphia Eagles vs. Green Bay Packers | Monday, November 10th, 2025 at 8:15pm ET |
| Week 11 | Detroit Lions vs. Philadelphia Eagles | Sunday, November 16th, 2025 at 8:20pm ET |
| Week 12 | Philadelphia Eagles vs. Dallas Cowboys | Sunday, November 23rd, 2025 at 4:25pm ET |
| Week 13 | Chicago Bears vs. Philadelphia Eagles | Friday, November 28th, 2025 at 3:00pm ET |
| Week 14 | Philadelphia Eagles vs. Los Angeles Chargers | Monday, December 8th, 2025 at 8:15pm ET |
| Week 15 | Las Vegas Raiders vs. Philadelphia Eagles | Sunday, December 14th, 2025 at 1:00pm ET |
| Week 16 | Philadelphia Eagles vs. Washington Commanders | Saturday, December 20th, 2025 at 5:00pm ET |
| Week 17 | Philadelphia Eagles vs. Buffalo Bills | Sunday, December 28th, 2025 at 4:25pm ET |
| Week 18 | Washington Commanders vs. Philadelphia Eagles | Sunday, January 4th, 2026 at 1:00pm ET |
