| Week 1 | Philadelphia Eagles vs. Detroit Lions | Sunday, September 11th, 2022 at 1:00pm ET |
| Week 2 | Minnesota Vikings vs. Philadelphia Eagles | Monday, September 19th, 2022 at 8:30pm ET |
| Week 3 | Philadelphia Eagles vs. Washington Commanders | Sunday, September 25th, 2022 at 1:00pm ET |
| Week 4 | Jacksonville Jaguars vs. Philadelphia Eagles | Sunday, October 2nd, 2022 at 1:00pm ET |
| Week 5 | Philadelphia Eagles vs. Arizona Cardinals | Sunday, October 9th, 2022 at 4:25pm ET |
| Week 6 | Dallas Cowboys vs. Philadelphia Eagles | Sunday, October 16th, 2022 at 8:20pm ET |
| Week 7 | Bye Week | |
| Week 8 | Pittsburgh Steelers vs. Philadelphia Eagles | Sunday, October 30th, 2022 at 1:00pm ET |
| Week 9 | Philadelphia Eagles vs. Houston Texans | Thursday, November 3rd, 2022 at 8:15pm ET |
| Week 10 | Washington Commanders vs. Philadelphia Eagles | Monday, November 14th, 2022 at 8:15pm ET |
| Week 11 | Philadelphia Eagles vs. Indianapolis Colts | Sunday, November 20th, 2022 at 1:00pm ET |
| Week 12 | Green Bay Packers vs. Philadelphia Eagles | Sunday, November 27th, 2022 at 8:20pm ET |
| Week 13 | Tennessee Titans vs. Philadelphia Eagles | Sunday, December 4th, 2022 at 1:00pm ET |
| Week 14 | Philadelphia Eagles vs. New York Giants | Sunday, December 11th, 2022 at 1:00pm ET |
| Week 15 | Philadelphia Eagles vs. Chicago Bears | Sunday, December 18th, 2022 at 1:00pm ET |
| Week 16 | Philadelphia Eagles vs. Dallas Cowboys | Saturday, December 24th, 2022 at 4:25pm ET |
| Week 17 | New Orleans Saints vs. Philadelphia Eagles | Sunday, January 1st, 2023 at 1:00pm ET |
| Week 18 | New York Giants vs. Philadelphia Eagles | Sunday, January 8th, 2023 at 4:25pm ET |
