| Week 1 | San Francisco 49ers vs. Seattle Seahawks | Sunday, September 7th, 2025 at 4:05pm ET |
| Week 2 | Seattle Seahawks vs. Pittsburgh Steelers | Sunday, September 14th, 2025 at 1:00pm ET |
| Week 3 | New Orleans Saints vs. Seattle Seahawks | Sunday, September 21st, 2025 at 4:05pm ET |
| Week 4 | Seattle Seahawks vs. Arizona Cardinals | Thursday, September 25th, 2025 at 8:15pm ET |
| Week 5 | Tampa Bay Buccaneers vs. Seattle Seahawks | Sunday, October 5th, 2025 at 4:05pm ET |
| Week 6 | Seattle Seahawks vs. Jacksonville Jaguars | Sunday, October 12th, 2025 at 1:00pm ET |
| Week 7 | Houston Texans vs. Seattle Seahawks | Monday, October 20th, 2025 at 10:00pm ET |
| Week 8 | Bye Week | |
| Week 9 | Seattle Seahawks vs. Washington Commanders | Sunday, November 2nd, 2025 at 8:20pm ET |
| Week 10 | Arizona Cardinals vs. Seattle Seahawks | Sunday, November 9th, 2025 at 4:05pm ET |
| Week 11 | Seattle Seahawks vs. Los Angeles Rams | Sunday, November 16th, 2025 at 4:05pm ET |
| Week 12 | Seattle Seahawks vs. Tennessee Titans | Sunday, November 23rd, 2025 at 1:00pm ET |
| Week 13 | Minnesota Vikings vs. Seattle Seahawks | Sunday, November 30th, 2025 at 4:05pm ET |
| Week 14 | Seattle Seahawks vs. Atlanta Falcons | Sunday, December 7th, 2025 at 1:00pm ET |
| Week 15 | Indianapolis Colts vs. Seattle Seahawks | Sunday, December 14th, 2025 at 4:25pm ET |
| Week 16 | Los Angeles Rams vs. Seattle Seahawks | Thursday, December 18th, 2025 at 8:15pm ET |
| Week 17 | Seattle Seahawks vs. Carolina Panthers | Sunday, December 28th, 2025 at 1:00pm ET |
| Week 18 | Seattle Seahawks vs. San Francisco 49ers | Sunday, January 4th, 2026 at 1:00pm ET |
