| Week 1 | New York Giants vs. Washington Commanders | Sunday, September 7th, 2025 at 1:00pm ET |
| Week 2 | Washington Commanders vs. Green Bay Packers | Thursday, September 11th, 2025 at 8:15pm ET |
| Week 3 | Las Vegas Raiders vs. Washington Commanders | Sunday, September 21st, 2025 at 1:00pm ET |
| Week 4 | Washington Commanders vs. Atlanta Falcons | Sunday, September 28th, 2025 at 1:00pm ET |
| Week 5 | Washington Commanders vs. Los Angeles Chargers | Sunday, October 5th, 2025 at 4:25pm ET |
| Week 6 | Chicago Bears vs. Washington Commanders | Monday, October 13th, 2025 at 8:15pm ET |
| Week 7 | Washington Commanders vs. Dallas Cowboys | Sunday, October 19th, 2025 at 4:25pm ET |
| Week 8 | Washington Commanders vs. Kansas City Chiefs | Monday, October 27th, 2025 at 8:15pm ET |
| Week 9 | Seattle Seahawks vs. Washington Commanders | Sunday, November 2nd, 2025 at 8:20pm ET |
| Week 10 | Detroit Lions vs. Washington Commanders | Sunday, November 9th, 2025 at 4:25pm ET |
| Week 11 | Washington Commanders vs. Miami Dolphins | Sunday, November 16th, 2025 at 9:30am ET |
| Week 12 | Bye Week | |
| Week 13 | Denver Broncos vs. Washington Commanders | Sunday, November 30th, 2025 at 8:20pm ET |
| Week 14 | Washington Commanders vs. Minnesota Vikings | Sunday, December 7th, 2025 at 1:00pm ET |
| Week 15 | Washington Commanders vs. New York Giants | Sunday, December 14th, 2025 at 1:00pm ET |
| Week 16 | Philadelphia Eagles vs. Washington Commanders | Saturday, December 20th, 2025 at 5:00pm ET |
| Week 17 | Dallas Cowboys vs. Washington Commanders | Thursday, December 25th, 2025 at 1:00pm ET |
| Week 18 | Washington Commanders vs. Philadelphia Eagles | Sunday, January 4th, 2026 at 1:00pm ET |
